The Prognostic Utility of Mean Platelet Volume in Patients With Acute Coronary Syndrome: A Systematic Review With Meta-Analyses
Galimzhanov A. Tenekecioglu E. Rustamova F. Tun H.N. Mamas M.A.
September 2022SAGE Publications Inc.
Angiology
2022#73Issue 8734 - 743 pp.
Mean platelet volume (MPV) is a hematological index that is routinely measured in clinical settings. Although many studies have been conducted to investigate the prognostic significance of MPV in acute coronary syndromes (ACS), the findings have been inconsistent. The goal of this study was to systematically review all current evidence on the association between admission MPV and clinical outcomes after ACS. PubMed, Scopus, Web of Science, and other databases were searched. The primary endpoints were major adverse cardiovascular events (MACE) and mortality. We applied a Knapp and Hartung adjustment, prediction interval calculations and permutation tests during pairwise meta-analyses. A one-stage dose–response meta-analysis was also conducted. The meta-analysis consisted of 41 studies with 33443 participants. Mean platelet volume, as a continuous variable, was associated with the risk of long-term mortality (hazard ratio 1.33, 95% CI 1.19–1.48). After conducting permutation tests and calculation of prediction intervals, this association remained significant. The results for MACE were nonsignificant. Linear models were the best fitted models during dose–response meta-analyses, trends for nonlinearity were significant for long-term endpoints. Admission MPV was associated with long-term mortality in ACS patients, with nonlinear associations between MPV levels and long-term clinical outcomes.
acute coronary syndrome , mean platelet volume , meta-analysis , mortality , myocardial infarction , platelets
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Department of Cardiology and Interventional Arrhythmology, Semey Medical University, Semey, Kazakhstan
Department of Cardiology, Bursa Education and Research Hospital Health Sciences University, Bursa, Turkey
Department of Internal Disease, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Larner College of Medicine, University of Vermont, Burlington, VT, United States
Keele Cardiovascular Research Group, Keele University, United Kingdom
Department of Cardiology and Interventional Arrhythmology
Department of Cardiology
Department of Internal Disease
Larner College of Medicine
Keele Cardiovascular Research Group
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