Nucleocapsid Protein of SARS-CoV-2 Upregulates RANTES Expression in A172 Glioblastoma Cells
Gadilgereyeva B. Kunushpayeva Z. Abdrakhmanova M. Khassenova A. Minigulov N. Burster T. Filchakova O.
March 2025Multidisciplinary Digital Publishing Institute (MDPI)
Molecules
2025#30Issue 5
SARS-CoV-2, the pathogenic virus that induces COVID-19 disease, contains four structural proteins in its virion. The nucleocapsid (N) protein is one of the four structural proteins that play a crucial role in the assembly of viral RNA into ribonucleoprotein. In addition, the N protein contributes to viral pathogenesis. One of the functions attributed to the N protein is the triggering of cytokine release by lung epithelial cells, macrophages, and monocytes. This study addresses the cellular effects of the N protein of SARS-CoV-2 on cells of glial origin. We report the upregulation of the RANTES chemokine in A172 glioblastoma cells at both the mRNA and protein levels in response to exposure to SARS-CoV-2 nucleocapsid protein. The N protein did not have an effect on cell viability and cell migration.
coronaviruses , glioblastoma , nucleocapsid protein , RANTES , SARS-CoV-2
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Biology Department, School of Sciences and Humanities, Nazarbayev University, Kabanbay Batyr ave., 53, Astana, 010000, Kazakhstan
Biology Department
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