Retrospective comparison of rectal toxicity between carbon-ion radiotherapy and intensity-modulated radiation therapy based on treatment plan, normal tissue complication probability model, and clinical outcomes in prostate cancer
Fukata K. Kawamura H. Kubo N. Kanai T. Torikoshi M. Nakano T. Tashiro M. Ohno T.
October 2021Associazione Italiana di Fisica Medica
Physica Medica
2021#906 - 12 pp.
This retrospective study assessed the treatment planning data and clinical outcomes for 152 prostate cancer patients: 76 consecutive patients treated by carbon-ion radiation therapy and 76 consequtive patients treated by moderate hypo-fractionated intensity-modulated photon radiation therapy. These two modalities were compared using linear quadratic model equivalent doses in 2 Gy per fraction for rectal or rectal wall dose–volume histogram, 3.6 Gy per fraction-converted rectal dose–volume histogram, normal tissue complication probability model, and actual clinical outcomes. Carbon-ion radiation therapy was predicted to have a lower probability of rectal adverse events than intensity-modulated photon radiation therapy based on dose–volume histograms and normal tissue complication probability model. There was no difference in the clinical outcome of rectal adverse events between the two modalities compared in this study.
Carbon-ion radiation therapy , Normal tissue complication probability , Prostate cancer
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Cancer Center, School of Medicine, Keio University, Tokyo, Japan
Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma, Japan
Section of Medical Physics and Engineering, Kanagawa Cancer Center, Yokohama, Japan
Gunma University Heavy Ion Medical Center, Gunma, Japan
Osaka Heavy Ion Therapy Center, Osaka, Japan
International Science and Technology Center, Nur-Sultan, Kazakhstan
Quantum Life and Medical Science Directorate, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan
Cancer Center
Department of Radiation Oncology
Section of Medical Physics and Engineering
Gunma University Heavy Ion Medical Center
Osaka Heavy Ion Therapy Center
International Science and Technology Center
Quantum Life and Medical Science Directorate
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