Gene Expression Changes in the Spleen, Lungs, and Liver of Wistar Rats Exposed to β-Emitted31SiO2 Particles
Fujimoto N. Mukhanbetzhanov N. Zhetkenev S. Chulenbayeva L. Fazylov T. Mukhortov M. Sato H. Zhumadilov K. Stepanenko V. Kaprin A. Ivanov S. Shegay P. Hoshi M. Kushugulova A.
March-2 2025Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
2025#26Issue 6
To understand the biological effects of residual radioactivity after the atomic bomb explosion in Hiroshima and Nagasaki, we previously investigated the effects of56Mn, a major residual radioisotope. Our rat study demonstrated that inhalation exposure to56MnO2 microparticles affected gene expression in the lungs, testes, and liver, despite the low radiation doses. Because56Mn is a β-and γ-emitter, the differential effects between β-and γ-rays should be clarified. In this study,31Si, a β-emitter with a radioactive half-life similar to that of56Mn, was used to determine its effects. Male Wistar rats were exposed to sprayed neutron-activated31SiO2 microparticles, stable SiO2 microparticles, or X-rays. The animals were examined on days 3 and 14 after irradiation. The expression of radiation-inducible marker genes, including Ccng1, Cdkn1a, and Phlda3, was measured in the spleen, lungs, and liver. Furthermore, the expressions of pathophysiological marker genes, including Aqp1, Aqp5, and Smad7 in the lungs and Cth, Ccl2, and Nfkb1 in the liver, were determined. Impacts of31SiO2 exposure were observed mainly in the liver, where the expression of Cth markedly increased on post-exposure days 3 and 14. Our data suggest that internal exposure to β-emitted microparticles has significant biological effects and its possible roles as residual radiation after atomic bombing.
31Si , 31SiO2 microparticles , atomic bomb , internal irradiation , residual radiation
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Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, 734-8553, Japan
Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, Z05H0P9, Kazakhstan
B. Atchabarov Scientific Research Institute of Fundamental and Applied Medicine, Asfendiyarov Kazakh National Medical University, Tole Bi Street 94, Almaty, 050012, Kazakhstan
Institute of Nuclear Physics of the Ministry of Energy of the Republic of Kazakhstan, Almaty, 050032, Kazakhstan
Faculty of Health Sciences, Ibaraki Prefectural University of Health Sciences, Ami-machi, Inashiki-gun, Ibaraki, 300-0394, Japan
Department of Nuclear Physics, L.N. Gumilyov Eurasian National University, Astana, 010000, Kazakhstan
A. Tsyb Medical Radiological Research Center, Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 4 Koroleva St, Kaluga, Obninsk, 249036, Russian Federation
National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Koroleva Str., 4, Kaluga, Obninsk, 249036, Russian Federation
Peoples’ Friendship, University of Russia, 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation
P.A. Hertzen Moscow Oncology Research Institute-Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 2nd Botkinsky Drive 3, Moscow, 125284, Russian Federation
The Center for Peace, Hiroshima University, Higashisenda-machi 1-1-89, Naka-ku, Hiroshima, 730-0053, Japan
Institute for Radiation Biology and Medicine
Center for Life Sciences
B. Atchabarov Scientific Research Institute of Fundamental and Applied Medicine
Institute of Nuclear Physics of the Ministry of Energy of the Republic of Kazakhstan
Faculty of Health Sciences
Department of Nuclear Physics
A. Tsyb Medical Radiological Research Center
National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Peoples’ Friendship
P.A. Hertzen Moscow Oncology Research Institute-Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
The Center for Peace
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