Biological impacts on the lungs in rats internally exposed to radioactive 56MnO2 particle
Fujimoto N. Ruslanova B. Abishev Z. Chaizhunussova N. Shabdarbayeva D. Amantayeva G. Farida R. Sandybayev M. Nagano K. Zhumadilov K. Kaprin A. Ivanov S. Stepanenko V. Hoshi M.
December 2021Nature Research
Scientific Reports
2021#11Issue 1
To understand the radiation effects of the atomic bombing of Hiroshima and Nagasaki among the survivors, radiation from neutron-induced radioisotopes in soil should be considered in addition to the initial radiation directly received from the bombs. 56Mn, which emits both β particles and γ-rays, is one of the dominant radioisotopes created in soil by neutrons from the bomb. Thus we investigated the biological effects of internal exposure to 56MnO2 particle in the lung of male Wistar rats comparing to the effects of external 60Co-γ irradiation. Absorbed doses of internal irradiation of lungs were between 25 and 65 mGy in 56MnO2-exposed animals, while the whole body doses were between 41 and 100 mGy. Animals were examined on days 3 and 61 after the exposure. There were no remarkable pathological changes related to 56MnO2 particle exposure. However, mRNA and protein expressions of aquaporin 5 increased significantly in the lung tissue on day 3 postexposure in 56MnO2 groups (by 1.6 and 2.9 times, respectively, in the highest dose group). Smad7 mRNA expression was also significantly elevated by 30% in the highest dose group of 56MnO2. Our data demonstrated that internal exposure to 56MnO2 induced significant biological responses including gene expression changes in the lungs, while external 60Co-γ irradiation of 2 Gy did not show any changes.
Text of the article Перейти на текст статьи
Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
Semey Medical University, Semey, Kazakhstan
Center of Nuclear Medicine and Oncology of Semey, Semey, Kazakhstan
Nagano Toxicologic-Pathology Consulting, Kanagawa, Japan
L.N. Gumilyov Eurasian National University, Nur-Sultan, Kazakhstan
National Medical Research Center of Radiology, Ministry of Health of Russian Federation, Obninsk, Russian Federation
The Center for Peace, Hiroshima University, Hiroshima, Japan
Research Institute for Radiation Biology and Medicine
Semey Medical University
Center of Nuclear Medicine and Oncology of Semey
Nagano Toxicologic-Pathology Consulting
L.N. Gumilyov Eurasian National University
National Medical Research Center of Radiology
The Center for Peace
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026