Efficacy of PGT in IVF cycles: experience of clinics group
Firsova N.V. Nigmatova N.P. Safronova K.A. Gartsman A.A. Kanbekova O.R. Balyberdina M.A. Gordeeva I.V. Shchigolev V.N.
2021Media Sphera Publishing Group
Russian Journal of Human Reproduction
2021#27Issue 6115 - 124 pp.
Introduction. The good IVF laboratory is the one offering preimplantation genetic testing (PGT) service. However, large-scale IVF cen-ters can afford the expense of equipment and software, the strong skills and knowledge of professionals including analysis and inter-pretation of bioinformatics data. Here, we report the experience of Genom clinics group with PGT cycles on transport scheme. Aim of study. To assess the efficacy of PGT in IVF cycles in different age groups. Material and methods. In retrospective cohort study 550 embryos were included. Four groups were created based on maternal age: 1st group ≤32 years old (n=166), 2nd group 33—35 years (n=135), 3rd group 36—40 years (n=143) and 4th group ≥41years (n=106). Only good quality blastocysts were subjected for biopsy (Grade AA, AB, BA, BB). Genetic testing was conducted by NGS platform. Statistical analysis included one-way ANOVA test. P-value <0.05 was considered statistically significant. Results. Euploidy rate in the 1st group was 56.6%, in the 2nd group — 50.3%, in the 3rd group — 48.2% and in the 4th group — 24.5%; although, euploidy rates among age group do not differ statistically (P-value = 0.462). Clinical pregnancy rate and livebirth in the 1st group 65.3% and 48%, in the 2nd group — 47.5% and 37.8%, in the 3rd group — 50.6% and 37.3% and in the 4th group — 43.5% and 43.5% respectively. These results do not differ statistically between age groups, P-value = 0.228 and 0.731 respectively. Success-ful biopsy rate was 98.7%. Conclusions. The results demonstrate decrease in the number of euploid embryos with increase in maternal age. The highest efficacy of PGT is observed in the 4th group (≥41 years). The clinical pregnancy rate and livebirth fluctuate among clinics, perhaps, due to other factors as well. Three-year experience with PGT cycles on transport scheme demonstrates that collaboration between IVF and genetic laboratories is a feasible option.
biopsy , infertility , IVF , PGT , PGT-A , TE (trophectoderm)
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«Alyans Clinic» reproduction center, Ulyanovsk, Russian Federation
«Genom-Astana» human reproduction center, Nur-Sultan, Kazakhstan
«Genom-Volga» reproduction center, Volgograd, Russian Federation
«Genom-Balt» reproduction center, Kaliningrad, Russian Federation
«Genom-Tomsk» human reproduction unit, Tomsk, Russian Federation
«Genom-Don» human reproduction center, Rostov-On-Don, Russian Federation
«Genom», MedMa company group, Moscow, Russian Federation
«Alyans Clinic» reproduction center
«Genom-Astana» human reproduction center
«Genom-Volga» reproduction center
«Genom-Balt» reproduction center
«Genom-Tomsk» human reproduction unit
«Genom-Don» human reproduction center
«Genom»
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