Radiochemical Investigations for Radiopharmaceutical Nuclear Medicine at JINR Laboratory of Nuclear Problems
Filosofov D.V. Baimukhanova A.E. Kurakina E.S. Karaivanov D.V. Velichkov A.I. Radchenko V.I. Yakushev E.A.
April 2023Pleiades Publishing
Physics of Particles and Nuclei
2023#54Issue 2321 - 363 pp.
Abstract: In recent years, radiopharmaceuticals have been increasingly used for diagnostics and treatment of cancer. In addition to a biological vector, a modern radiopharmaceutical includes a chelator that binds the radionuclide, as well as a linker for connecting the vector and the chelator. The development of such an approach requires the improvement of methods for obtaining and purifying radionuclides, and the development of methods for the synthesis of radiopharmaceuticals, i.e., preparative direction. It is also necessary to search for new vectors and chelators. This implies the development of methods for analyzing the properties of radiopharmaceuticals in general, as well as their precursors, i.e., analytical direction. In this review, we describe the prerequisites for successfully solving a wide range of challenges in these two areas of nuclear medicine at the Scientific and Experimental Department of Nuclear Spectroscopy and Radiochemistry of the Laboratory of Nuclear Problems of the Joint Institute for Nuclear Research (LNP JINR). These prerequisites are due to rich experience in obtaining the widest range of radionuclides and their application for various spectrometric studies. Both the past and present works on radiopharmaceutical topics carried out in the department are described, and ways of future development are outlined.
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Joint Institute for Nuclear Research, Moscow oblast, Dubna, 141980, Russian Federation
Institute of Nuclear Physics, Almaty, 050032, Kazakhstan
Mendeleev University of Chemical Technology, Moscow, 125480, Russian Federation
Institute for Nuclear Research and Nuclear Energy, Sofia, 1784, Bulgaria
The University of British Columbia, West Mall 2329, Vancouver, V6T 1Z4, Canada
Joint Institute for Nuclear Research
Institute of Nuclear Physics
Mendeleev University of Chemical Technology
Institute for Nuclear Research and Nuclear Energy
The University of British Columbia
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