Pharmacological, toxicological and phytochemical analysis of Spondias dulcis parkinson
Fernandes F.H.A. Soares S.D.S. Bekbolatova E. Boylan F. Salgado H.R.N.
2024Taylor and Francis Ltd.
Natural Product Research
2024#38Issue 61049 - 1053 pp.
Spondias dulcis Parkinson have been used in traditional medicine in Asia, Oceania, and South America, for different diseases conditions and as a functional food. The scientific literature described as different potential pharmacology such as antioxidant, anti-inflammatory, antimicrobial, thrombolytic and enzymatic inhibitor. This study aimed to: (1) establish the pharmacological activity in intestinal motility in vivo and antioxidant activity in vitro; (2) perform the acute toxicology test in mouse; (3) characterize the phytochemical profile based on counter-current chromatography (CCC) and NMR analysis. The results revealed a laxative effect of S. dulcis extract and a high antioxidant activity (IC50 = 5.10 for DPPH assay and 14.14 for hydrogen peroxide scavenging test). No side effects were observed in the oral acute toxicity test for a dose up to 2000 mg/kg. The chemical profile was identified by CCC and NMR, and the comparison of the data obtained with previous literature revealed the presence of the flavonoid rutin (Quercetin-3-O-rutinoside) in the extract.
antioxidant activity , countercurrent chromatography , Laxative activity , rutin
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School of Pharmacy, São Paulo State University (UNESP), São Paulo, Araraquara, Brazil
UNIFACISA Centro Universitário, Paraíba, Campina Grande, Brazil
Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany
School of Pharmacy, JSC National Medical University, Almaty, Kazakhstan
School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
School of Pharmacy
UNIFACISA Centro Universitário
Medical Faculty Mannheim
School of Pharmacy
School of Pharmacy and Pharmaceutical Sciences
10 лет помогаем публиковать статьи Международный издатель
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