Thyroid disease as a comorbidity in inflammatory rheumatic diseases
Fedorchenko Y. Yessirkepov M. Doskaliuk B. Zaiats L. Mahmudov K.
March 2025Springer Science and Business Media Deutschland GmbH
Rheumatology International
2025#45Issue 3
Thyroid disease is a common comorbidity in inflammatory rheumatic diseases (IRDs). It complicates disease management and treatment of IRDs. The interplay between thyroid disfunction and IRDs is confounded by shared autoimmune mechanisms and systemic inflammation. Available evidence suggests that rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and systemic sclerosis (SSc) are associated with an elevated risk of hypothyroidism, hyperthyroidism, and autoimmune thyroid disease (AITD). This review explores mechanisms of thyroid disease in IRDs, overviews implications for disease management, and highlights approaches to optimal patient outcomes. Recent studies point to the need for routine thyroid screening in high-risk IRD populations and justify therapies with anti-TNF-α and anti-IL-17 agents, targeting both thyroid disease and IRDs. This integrated management strategy is crucial for optimizing therapeutic approaches in overlapping autoimmune conditions.
Autoimmune thyroid disease , Rheumatic diseases , Rheumatoid arthritis , Systemic lupus erythematosus , Thyroid hormone
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Department of Pathophysiology, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
Department of Biology and Biochemistry, South Kazakhstan Medical Academy, Shymkent, Kazakhstan
Department of Propaedeutics of Internal Diseases, Avicenna Tajik State Medical University, Dushanbe, Tajikistan
Department of Pathophysiology
Department of Biology and Biochemistry
Department of Propaedeutics of Internal Diseases
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