Pregnancy and Birth Outcomes in Patients With Multidrug-Resistant Tuberculosis Treated With Regimens That Include New and Repurposed Drugs
Farrukh I.L. Lachenal N. Adenov M.M. Ahmed S. Algozhin Y. Coutisson S. Garavito E.S. Hewison C. Holtzman D. Huerga H. Janmohamed A. Khan P.Y. Jacques G.L. Lomtadze N. Melikyan N. Mitnick C.D. Mussabekova G. Osso E. Perea S. Putri F.A. Rashidov M. Rich M.L. Sakhabutdinova Y. Seung K.J. Stambekova A. Vásquez D.V. Franke M.F. Khan U.
15 January 2024Oxford University Press
Clinical Infectious Diseases
2024#78Issue 1144 - 148 pp.
Among 43 pregnant women receiving multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) treatment with bedaquiline and/or delamanid, 98% had favorable treatment outcomes. Of 31 continued pregnancies, 81% had live births with no reported malformations, and 68% of neonates had normal birth weights. Effective MDR/RR-TB treatment during pregnancy can improve maternal outcomes without harming neonates.
drug resistance , outcome , pregnancy , treatment , tuberculosis
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Interactive Research and Development Pakistan, Karachi, Pakistan
Pharmacovigilance Unit, Medecins Sans Frontières, Geneva, Switzerland
National Scientific Center of Phthisiopulmonology, Ministry of Health, Almaty, Kazakhstan
Partners in Health, Almaty, Kazakhstan
Centro de Investigación de Enfermedades Neumológicas, Hospital Nacional Sergio Bernale, Lima, Peru
Medical Department, Medecins Sans Frontières, Paris, France
Partners in Health, Maseru, Lesotho
Field Epidemiology Department, Epicentre, Paris, France
London School of Hygiene & Tropical Medicine, London, United Kingdom
Zanmi Lasante Cange, Haiti
Surveillance and Strategic Planning, Ministry of Health, Tbilisi, Georgia
Field Epidemiology Department, Epicentre, Yerevan, Armenia
Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, United States
Partners in Health, Boston, MA, United States
Socios en Salud Sucursal Peru, Lima, Peru
Interactive Research and Development Global, Jakarta, Indonesia
Division of Global Health Equity, Brigham and Womens Hospital, Boston, MA, United States
Centro de Investigación, Hospital Nacional Hipólito Unanue, Lima, Peru
Interactive Research and Development Pakistan
Pharmacovigilance Unit
National Scientific Center of Phthisiopulmonology
Partners in Health
Centro de Investigación de Enfermedades Neumológicas
Medical Department
Partners in Health
Field Epidemiology Department
London School of Hygiene & Tropical Medicine
Zanmi Lasante Cange
Surveillance and Strategic Planning
Field Epidemiology Department
Department of Global Health and Social Medicine
Partners in Health
Socios en Salud Sucursal Peru
Interactive Research and Development Global
Division of Global Health Equity
Centro de Investigación
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