Suppressive effects of bioactive herbal polysaccharides against different cancers: From mechanisms to translational advancements
Farooqi A.A. Rakhmetova V. Kapanova G. Mussakhanova A. Tashenova G. Tulebayeva A. Akhenbekova A. Xu B.
February 2023Elsevier GmbH
Phytomedicine
2023#110
Background: Fueled by rapidly evolving comprehension of multifaceted nature of cancers, recently emerging preclinical and clinical data have supported researchers in the resolution of knowledge gaps to deepen the understanding of the molecular mechanisms. The extra-ordinary and bewildering chemical diversity encompassed by biologically active natural products continues to be of relevance to drug discovery. Accumulating evidence has spurred a remarkable evolution of concepts related to pharmacological target of oncogenic signaling pathways by polysaccharides in different cancers. Purpose: The objective of the current review is to provide new insights into study progress on anticancer effects of bioactive herbal polysaccharides. Methods: PubMed, Scopus, Web of Science, Embase, and other databases were searched for articles related to anticancer effects of polysaccharides. Searches were conducted to locate relevant publications published up to October 2022. Results: Polysaccharides have been reported to pleiotropically modulate TGF/SMAD, BMP/SMAD, TLR4, mTOR, CXCR4 and VEGF/VEGFR cascades. We have also summarized how different polysaccharides regulated apoptosis and non-coding RNAs. Additionally, this mini-review describes increasingly sophisticated understanding related to polysaccharides mediated tumor suppressive and anti-metastatic effects in tumor-bearing mice. We have also provided an overview of the clinical trials related to chemopreventive role of polysaccharides. Conclusion: Genomic and proteomic findings from these studies will facilitate ‘next-generation’ clinical initiatives in the prevention/inhibition of cancer.
Polysaccharides , Signaling cascades , Tumor suppressive effects
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Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan
Medical University of Astana, Kazakhstan
Al-Farabi Kazakh National University, 71 al-Farabi Ave, Almaty, 050040, Kazakhstan
Scientific Center of Anti-infectious Drugs, 75 a al-Faraby Ave, Almaty, 050040, Kazakhstan
Department of Public Health and Management, Astana Medical University, Astana, Kazakhstan
Asfendiyarov Kazakh National Medical University, Kazakhstan
JSC Scientific Center of Pediatrics and Pediatric Surgery, Kazakhstan
Food Science and Technology Program, Department of Life Sciences, BNU-HKBU United International College, 2000, Jintong Road, Tangjiawan, Zhuhai, 519087, Guangdong, China
Institute of Biomedical and Genetic Engineering (IBGE)
Medical University of Astana
Al-Farabi Kazakh National University
Scientific Center of Anti-infectious Drugs
Department of Public Health and Management
Asfendiyarov Kazakh National Medical University
JSC Scientific Center of Pediatrics and Pediatric Surgery
Food Science and Technology Program
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