Regulation of RUNX proteins by long non-coding RNAs and circular RNAs in different cancers
Farooqi A.A. Gulnara K. Mukhanbetzhanovna A.A. Datkhayev U. Kussainov A.Z. Adylova A.
June 2021KeAi Communications Co.
Non-coding RNA Research
2021#6Issue 2100 - 106 pp.
RUNX proteins have been shown to behave as “double-edge sword” in wide variety of cancers. Discovery of non-coding RNAs has played linchpin role in improving our understanding about the post-transcriptional regulation of different cell signaling pathways. Several new mechanistic insights and distinct modes of cross-regulation of RUNX proteins and non-coding RNAs have been highlighted by recent research. In this review we have attempted to provide an intricate interplay between non-coding RNAs and RUNX proteins in different cancers. Better conceptual and mechanistic understanding of layered regulation of RUNX proteins by non-coding RNAs will be helpful in effective translation of the laboratory findings to clinically effective therapeutics.
Apoptosis , Cancer , Non-coding RNAs , Signaling , Therapy
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Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan
Al-Farabi Kazakh National University, 71 Al-Farabi Avenue, Almaty, 050040, Kazakhstan
Department of Healthcare Management, KSPH Kazakhstan Medical University, Almaty, Kazakhstan
Asfendiyarov Kazakh National Medical University, KazNMU, Tole Bi St 94, Almaty, 050000, Kazakhstan
Kazakh National Medical University Named After S. D. Asfendiyarov, Kazakhstan
Guangdong Key Laboratory for Genome Stability & Disease Prevention and Carson International Cancer Center, Shenzhen University School of Medicine, Shenzhen, 518060, Guangdong, China
Institute of Biomedical and Genetic Engineering (IBGE)
Al-Farabi Kazakh National University
Department of Healthcare Management
Asfendiyarov Kazakh National Medical University
Kazakh National Medical University Named After S. D. Asfendiyarov
Guangdong Key Laboratory for Genome Stability & Disease Prevention and Carson International Cancer Center
10 лет помогаем публиковать статьи Международный издатель
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