Regulation of RASSF by non-coding RNAs in different cancers: RASSFs as masterminds of their own destiny as tumor suppressors and oncogenes
Farooqi A.A. Kapanova G. Kussainov A.Z. Datkhayeva Z. Raganina K. Sadykov B.N.
June 2022KeAi Communications Co.
Non-coding RNA Research
2022#7Issue 2123 - 131 pp.
Ras-association domain family (RASSF) proteins are tumor suppressors and have gained phenomenal limelight because of their mechanistic role in the prevention/inhibition of carcinogenesis and metastasis. Decades of research have demystified wide ranging activities of RASSF molecules in multiple stages of cancers. Although major fraction of RASSF molecules has tumor suppressive roles, yet there is parallel existence of proof-of-concept about moonlighting activities of RASSF proteins as oncogenes. RASSF proteins tactfully rewire signaling cascades for prevention of cancer and metastasis but circumstantial evidence also illuminates oncogenic role of different RASSF proteins in different cancers. In this review we have attempted to provide readers an overview of the complex interplay between non-coding RNAs and RASSF proteins and how these versatile regulators shape the landscape of carcinogenesis and metastasis.
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Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan
Al-Farabi Kazakh National University, Almaty, 71 al-Farabi Ave, Almaty, 050040, Kazakhstan
Scientific Center of Anti-infectious Drugs, Kazakhstan, 75 a al-Faraby Ave, Almaty, 050040, Kazakhstan
Department of Pediatric Surgery, Kazakh National Medical University, Kazakhstan
Department of Obstetrics and Gynecology, Kazakh National Medical University, Kazakhstan
Department of Pharmaceutical Technology, Asfendiyarov Kazakh National Medical University, Kazakhstan
Department of General Surgery, Kazakhstan Medical University KSPH, Almaty, 050004, Kazakhstan
Institute of Biomedical and Genetic Engineering (IBGE)
Al-Farabi Kazakh National University
Scientific Center of Anti-infectious Drugs
Department of Pediatric Surgery
Department of Obstetrics and Gynecology
Department of Pharmaceutical Technology
Department of General Surgery
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