Regulation of Cell Signaling Pathways and Non-Coding RNAs by Baicalein in Different Cancers
Farooqi A.A. Kapanova G. Kalmakhanov S. Tanbayeva G. Zhakipbekov K.S. Rakhmetova V.S. Syzdykbayev M.K.
August 2022MDPI
International Journal of Molecular Sciences
2022#23Issue 15
Landmark discoveries in molecular oncology have provided a wide-angle overview of the heterogenous and therapeutically challenging nature of cancer. The power of modern ‘omics’ technologies has enabled researchers to deeply and comprehensively characterize molecular mechanisms underlying cellular functions. Interestingly, high-throughput technologies have opened new horizons for the design and scientific fool-proof evaluation of the pharmacological properties of targeted chemical compounds to tactfully control the activities of the oncogenic protein networks. Groundbreaking discoveries have galvanized the expansion of the repertoire of available pharmacopoeia to therapeutically target a myriad of deregulated oncogenic pathways. Natural product research has undergone substantial broadening, and many of the drugs which constitute the backbone of modern pharmaceuticals have been derived from the natural cornucopia. Baicalein has gradually gained attention because of its unique ability to target different oncogenic signal transduction cascades in various cancers. We have partitioned this review into different sub-sections to provide a broader snapshot of the oncogenic pathways regulated by baicalein. In this review, we summarize baicalein-mediated targeting of WNT/β-catenin, AKT/mTOR, JAK/STAT, MAPK, and NOTCH pathways. We also critically analyze how baicalein regulates non-coding RNAs (microRNAs and long non-coding RNAs) in different cancers. Finally, we conceptually interpret baicalein-mediated inhibition of primary and secondary growths in xenografted mice.
baicalein , cancer , cell signaling , metastasis , natural products
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Department of Molecular Oncology, Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, 44000, Pakistan
Scientific Center of Anti-Infectious Drugs, 75 al-Faraby Ave, Almaty, 050040, Kazakhstan
Al-Farabi Kazakh National University, 71 al-Farabi Ave, Almaty, 050040, Kazakhstan
Department of Organization and Management and Economics of Pharmacy and Clinical Pharmacy, Asfendiyarov Kazakh National Medical University KazNMU, Tole Bi St. 94, Almaty, 050000, Kazakhstan
Department Internal Diseases, Astana Medical University, Nur-Sultan, 010000, Kazakhstan
Department of Anesthesiology, Reanimatology and Narcology, Semey Medical University, Semey, 071400, Kazakhstan
Department of Molecular Oncology
Scientific Center of Anti-Infectious Drugs
Al-Farabi Kazakh National University
Department of Organization and Management and Economics of Pharmacy and Clinical Pharmacy
Department Internal Diseases
Department of Anesthesiology
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