Mechanistic Insights and Molecular Diagnostics of TMPRSS2-ERG: Overview of the Journey from Regulation of Signaling Landscape in Fusion Positive Prostate Cancer to Appraisal as a Diagnostic Marker

Farooqi A.A. Turgambayeva A. Almabayeva A. Zhanaliyeva M. Orakbay L. Shabanbayeva Z. Narmanova O. Syzdykbayev M.K.
October 2024 IMR Press Limited

Frontiers in Bioscience - Landmark
2024 #29 Issue 10

Chromosomal rearrangements and recurrent gene fusions were previously presumed to be the primary oncogenic mechanisms of hematological malignancies. However, the discovery of gene fusions in different cancers has opened new horizons to comprehensively investigate how cell type-specific fusion oncoproteins modulate signaling cascades. Prostate cancer (PCa) is a multifaceted and therapeutically challenging disease, and functional genomics have helped us develop a better understanding of the mechanisms underlying prostate carcinogenesis, castration-resistant PCa, and metastasis. Keeping in mind the fact that gene fusions have also been discovered in PCa, there has been rapid expansion in the field of molecular oncology and researchers are uncovering new facets regarding the mechanistic regulation of signaling pathways by fusion oncoproteins.

cancer , cell signaling , fused oncoproteins , metastasis , prostate cancer , therapeutics , therapy

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Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, 44000, Pakistan
Department Public Health and Management, NJSC, Medical University Astana, Astana, 010000, Kazakhstan
Department of Human Anatomy, NJSC “Astana Medical University”, Astana, 010000, Kazakhstan
Department of Hygiene and Epidemiology, Kazakh Russian Medical University, Almaty, 050004, Kazakhstan
Department of Anesthesiology, Reanimatology and Narcology, Semey Medical University, Semey, 071400, Kazakhstan

Institute of Biomedical and Genetic Engineering (IBGE)
Department Public Health and Management
Department of Human Anatomy
Department of Hygiene and Epidemiology
Department of Anesthesiology

10 лет помогаем публиковать статьи Международный издатель

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