Antimetastatic effects of Citrus-derived bioactive ingredients: Mechanistic insights
Farooqi A.A. Tahir F. Fakhar M. Butt G. Colombo Pimentel T. Wu N. Yulaevna I.M. Attar R.
31 August 2021NLM (Medline)
Cellular and molecular biology (Noisy-le-Grand, France)
2021#67Issue 2178 - 186 pp.
The growing complexity of metastasis has sparked tremendous interest in unraveling of the underlying mechanisms which play fundamental role in cancer progression and metastasis. Ground-breaking discoveries in metastasis research have greatly enhanced our understanding about intricate nature of metastasis. Bioactive chemicals obtained from citrus fruits have gained noteworthy appreciation because of significant cancer chemopreventive roles. Deregulated oncogenic signaling cascades play central role in metastasis. Emerging evidence has started to shed light on the metastasis inhibitory properties of naringin, naringenin, tangeretin, nobiletin, hesperidin and hesperetin in different cancer cell lines and xenografted mice. Wnt/?-catenin, TGF/SMAD and NOTCH signaling cascades have been shown to play linchpin role in carcinogenesis and metastasis. There is emerging evidence related to pharmacological targeting of Wnt/?-catenin, TGF/SMAD and NOTCH by citrus-derived bioactive components. These findings are indeed encouraging and will enable researchers to gain further insights into pharmacological targeting of oncogenic pathways to inhibit and prevent metastasis.
Text of the article Перейти на текст статьи
Department of Molecular Oncology, Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan
Independent Researcher..
Department of Botany, GCU, Lahore, Pakistan
Federal Institute of Paraná (IFPR), Campus Paranavaí, 87703-536, Paraná, Brazil
CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China
E. A. Buketov Karaganda University, Kazakhstan
Department of Obstetrics and Gynecology, Yeditepe University, Turkey
Department of Molecular Oncology
Independent Researcher..
Department of Botany
Federal Institute of Paraná (IFPR)
CAS and Shandong Province Key Laboratory of Experimental Marine Biology
E. A. Buketov Karaganda University
Department of Obstetrics and Gynecology
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026