Insights into the Engineered Gold Nanoparticle-Based Remedy for Supplementation Therapy of Ovarian Carcinoma
Farooq M.U. Dovzhenko A.P. Zairov R.R. Abyzbekova G. Harb M. Arkook B. Akylbekov N. Tapalova A. Makhlouf M.M.
30 July 2024American Chemical Society
ACS Omega
2024#9Issue 3033033 - 33043 pp.
Chronic diseases, notably cancer, pose a significant global threat to human life. Oncologists and medical professionals addressing malignancies confront challenges such as toxicity and multidrug resistance. To tackle these issues, the focus has shifted toward the employment of multifunctional colloidal gold nanoparticles. This study aims to design pH-sensitive doxorubicin-loaded gold nanoparticles using polyvinylpyrrolidone. The cytotoxic efficacy of the designed gold nanoarchitecture and its doxorubicin counterpart was assessed in an in vitro model using the HeLa cell. In comparison to the free drug, experimental evaluations showed that the gold nanoarchitecture outperformed significantly lower unspecific drug leaching and efficiently delivered the payload in a controlled manner, boosting the chemotherapy outcomes. This work opens a streamlined approach for engineering gold nanoarchitecture that could be further expanded to incorporate other therapeutics and/or functional moieties that require optimized controlled delivery, offering a one-size-fits-all solution and paving the revolutionary adjustments to healthcare procedures.(Figure Presented).
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School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China
A. M. Butlerov Institute of Chemistry, Kazan Federal University, Kazan, 420008, Russian Federation
Department of Biology, Geography and Chemistry, Korkyt Ata Kyzylorda University, Kyzylorda, 120014, Kazakhstan
Department of Sciences and Technology, Ranyah University College, Taif University, Taif, 21944, Saudi Arabia
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Kazan, 420088, Russian Federation
Department of Physics, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia
Laboratory of Engineering Profile “Physical and Chemical Methods of Analysis”, Korkyt Ata Kyzylorda University, Kyzylorda, 120014, Kazakhstan
School of Chemistry and Chemical Engineering
A. M. Butlerov Institute of Chemistry
Department of Biology
Department of Sciences and Technology
Arbuzov Institute of Organic and Physical Chemistry
Department of Physics
Laboratory of Engineering Profile “Physical and Chemical Methods of Analysis”
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