Magnetic Nanoparticles for Targeted Drug Delivery in a Mouse Model of Breast Cancer

Faisal F. Tatarinova G. Ugli T.D.M. Abdugabbarovna D.L. Ikhtiyorovna K.D. Normuminovna K.D. Boynazarovich M.R. Sapaev I.B. Rasulovna R.M. Ugli K.J.K. Aliyorovna G.J. Xamidovna M.D. Risaliyevich I.O.I.
2024 University of Kashan

Journal of Nanostructures
2024 #14 Issue 1 101 - 108 pp.

Targeted drug delivery using magnetic nanoparticles (MNPs) has emerged as a promising approach for cancer therapy. This study investigates the efficacy of MNPs for targeted delivery of doxorubicin (DOX) in a mouse model of breast cancer. MNPs were synthesized by co-precipitation and functionalized with DOX. The MNP-DOX conjugates were characterized using TEM, XRD, and FTIR. Female BALB/c mice (n=24) were inoculated with 4T1 breast cancer cells. The mice were divided into four groups: control, DOX, MNP, and MNP-DOX. Every 3 days over a 2-week period, intravenous administration of treatments occurred. Monitoring of tumor volume and body weight took place. Histological analysis and immunohistochemical staining for Ki-67 and caspase-3 were performed on tumor tissues. MNP-DOX conjugates were successfully synthesized and characterized, showing effective drug loading and release. Tumor growth was significantly inhibited in the MNP-DOX group compared to the control, DOX, and MNP groups. The MNP-DOX group exhibited the smallest tumor volume (135±28 mm³⁾ at the end of the treatment period. Histological analysis revealed increased necrosis and apoptosis in the MNP-DOX group. Immunohistochemical staining showed reduced Ki-67 expression and increased caspase-3 expression in the MNP-DOX group. MNPs functionalized with DOX demonstrated effective targeted drug delivery and enhanced therapeutic efficacy in a mouse model of breast cancer. The MNP-DOX conjugates significantly inhibited tumor growth, increased necrosis and apoptosis, and modulated Ki-67 and caspase-3 expression. These findings support the potential of MNPs as a promising platform for targeted cancer therapy. Further studies are needed to optimize the MNP formulation and assess its safety and efficacy in clinical settings. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Breast Cancer , Mouse Model , Targeted Drug Delivery , Tumor Growth

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Departement of Biology, Universitas Islam Malang, Indonesia
Docent Department of Anatomy with Physiology Courses, Kazakh-Russian Medical University, Almaty, Kazakhstan
Department of Oncology of the Andijan State Medical Institute, Andijan, Uzbekistan
Termez State University, Termez, Uzbekistan
Department of Physics of the Navoi state pedagogical institute, Navoi, Uzbekistan
Tashkent Institute of Irrigation and Agricultural Mechanization Engineers National Research University, Tashkent, Uzbekistan
University of Tashkent for Applied Sciences, Tashkent, Uzbekistan
Western Caspian University, Baku, Scientific researcher, Azerbaijan
Department Clinic Pharmacology, Bukhara State Medical University, Uzbekistan
Department of Fruits and Vegetables, Urganch State University, Uzbekistan
Department of Rehabilitation, Folk Medicine and Physical Education, Tashkent Medical Academy, Tashkent, Uzbekistan
Department of Pediatrics and Medical Genetics, Pediatric Faculty, Samarkand State Medical University, Uzbekistan
Tashkent Institute of Irrigation and Agricultural Mechanization Engineers National Research, University of Uzbekistan, Uzbekistan

Departement of Biology
Docent Department of Anatomy with Physiology Courses
Department of Oncology of the Andijan State Medical Institute
Termez State University
Department of Physics of the Navoi state pedagogical institute
Tashkent Institute of Irrigation and Agricultural Mechanization Engineers National Research University
University of Tashkent for Applied Sciences
Western Caspian University
Department Clinic Pharmacology
Department of Fruits and Vegetables
Department of Rehabilitation
Department of Pediatrics and Medical Genetics
Tashkent Institute of Irrigation and Agricultural Mechanization Engineers National Research

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