Synthesis and Biological Activity of Some Esters of Glycyrretinic Acid
Esanov R.S. Dzhuraev A.Zh. Rafikova Kh.S. Khashimova Z.S. Berdibaev E.Yu. Abdurazzakova D.S. Matchanov A.D.
October 2024Engineered Science Publisher
Engineered Science
2024#31
Synthetic transformations of bioactive natural compounds are one of the current areas of modern organic and bioorganic chemistry associated with the search for new structural types, substances and compounds with a wide range of biological activity. One of these natural compounds is 3β-hydroxy-11-oxo-12-en-18βН, 20β-olean-30 acid, 3-О-(2-҆О-β-D glucuronopyranosyl)-β-D-glucuronopyranoside (glycyrrhizic acid, GA) is the main active principle of licorice root (Glycyrrhiza GLAbra L.), which grows on the territory of the Republic of Uzbekistan and is a renewable natural source. With the ability to self-organize and recognize other particles and molecules, natural biologically active compounds are the subject of current chemical research aimed at modeling various biochemical processes. Various esters of Glycyrrhetic acid derivatives were synthesized. The chemical structures of the synthesized compounds were confirmed by ultraviolet (UV), infrared (IR) spectroscopy, and nuclear magnetic resonance (NMR) spectroscopy (13С and1Н). Substance 1 exhibits antiproliferative activity on HeLa cells. The inclusion of MTT in cells at 100 µl/ml of the medium is 55.21%, i.e. inhibition of cell growth is 44.8%.
3-acetoxyglycyrrhetic acid , Antiproliferative activity , Antitumor , Antiviral activity , Glycyrrhetic acid , HeLa cells
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Institute of Bioorganic Chemistry AS RUz 100125, Mirza Ulugbek avenue, Tashkent city, 83, Uzbekistan
National University of Uzbekistan, Tashkent, 100174, Uzbekistan
Gulistan State University, microdistrict 4, Gulistan, 120100, Uzbekistan
Satbayev University, Satpaev 22, Almaty, 050000, Kazakhstan
Tashkent State Agrarian University, Tashkent, 100138, Uzbekistan
Tashkent Medical Academy, Farabi 2, Tashkent, 100109, Uzbekistan
Alfraganus University, Tashkent, 100190, Uzbekistan
Institute of Bioorganic Chemistry AS RUz 100125
National University of Uzbekistan
Gulistan State University
Satbayev University
Tashkent State Agrarian University
Tashkent Medical Academy
Alfraganus University
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