HPV vaccination as a tool to reduce the global cancer burden: A literature review
Erlanova D. Abuova G. Ayazbekov A. Shaimerdenova G.
30 September 2025Kaz Med Print LLP
Reproductive Medicine (Central Asia)
2025#2025Issue 321 - 28 pp.
Relevance: Cervical cancer (CC), caused by the human papillomavirus (HPV), is the 4th most common cancer in the world. 95% of CC cases are associated with HPV. In total, 570,000 cases and 311,000 deaths from CC were recorded worldwide in 2018. Ineffective screening and treatment programs for CC in low-and medium-GDP countries account for 85% of cases and deaths. Second place after CC is occupied by oropharyngeal cancer associated with HPV (70% of cases). The study aimed to summarize and analyze the latest scientific findings on the effectiveness of vaccination against human papillomavirus. Materials and Methods: To conduct this literature review, three authors independently conducted a comprehensive analysis of scientific publications published in peer-reviewed journals and scientific databases, including PubMed, Scopus, Google Scholar, and Web of Science. Results: Some HPV types are classified as group 1 as carcinogenic to humans. The most oncogenic is HPV-16, which is most often associated with cancer development. Cervarix and GARDASIL HPV vaccines are the first vaccines for which efficacy has been assessed. Conclusion: Thus, preventive HPV vaccination is an effective strategy for combating oncogenic infections and requires further expansion of coverage within national health programs.
health care , human papillomavirus (HPV) , vaccination
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Department of Infectious Diseases and Dermatovenereology, South Kazakhstan Medical Academy, Shymkent, Kazakhstan
Department of Infectious Diseases and Dermatovenereology, Department of Infectious Diseases and Dermatovenereology, South Kazakhstan Medical Academy, Shymkent, Kazakhstan
Department of Surgical Diseases, Yasavi International Kazakh-Turkish University, Turkestan, Kazakhstan
Department of Infectious Diseases and Dermatovenereology
Department of Infectious Diseases and Dermatovenereology
Department of Surgical Diseases
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