Fluorescence-Guided Surgery to Detect Microscopic Disease in Ovarian Cancer: A Systematic Review with Meta-Analysis
Erdemoglu E. Langstraat C.L. Kumar A. Ostby S.A. Girardo M.E. Giannini A. Butler K.A.
February 2025Multidisciplinary Digital Publishing Institute (MDPI)
Cancers
2025#17Issue 3
The identification of tumors during cytoreductive surgery relies on visual inspection, palpation, or blind biopsy methods that exhibit limited reliability in detecting microscopic disease. Fluorescence-guided surgery (FGS) utilizes various tracers for the identification of microscopic disease. The objective of this study was to evaluate the efficacy of FGS in the detection of microscopic disease through meta-analyses, while discussing the existing evidence and potential implications for ovarian cancer. The pooled odds ratio of a change in surgical plan/microscopic disease for FGS, standard techniques, and peritonectomy was 1.29 and 1.14, respectively. Among the FGS tracers, folate receptors exhibited high sensitivity; however, their low specificity resulted in false positives. 5-Aminolevulinic acid exhibited high sensitivity (84%) and specificity (96%) in detecting microscopic disease. Standardized protocols and phase III trials are essential to determine the role of FGS in ovarian cancer. We discuss the significant variability in existing studies, the limitations of FGS, and the potential implications for future research.
5-ALA , EC17 , fluorescence-guided surgery , OTL38 , ovarian cancer , ovarian neoplasm , peritonectomy
Text of the article Перейти на текст статьи
Department of Medical and Surgical Gynecology, Mayo Clinic, Phoenix, 85054, AZ, United States
Department of Gynecologic Oncology, Suleyman Demirel University, Isparta, 32260, Kazakhstan
Department of Obstetrics and Gynecology, Division of Gynecologic Surgery, Mayo Clinic, Rochester, 55905, MN, United States
Department of Biostatistics, Mayo Clinic, Phoenix, 85054, AZ, United States
Division of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 56126, Italy
Department of Medical and Surgical Gynecology
Department of Gynecologic Oncology
Department of Obstetrics and Gynecology
Department of Biostatistics
Division of Obstetrics and Gynecology
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026