Steroid-sparing strategy for the treatment of vasculitis associated with antineutrophil cytoplasmic antibodies

Egorova O.N. Tarasova G.M. Datsina A.V. Issayeva B.G. Dilmanova D.S. Issayeva S.M. Lila A.M.
2024 Ima-Press Publishing House

Sovremennaya Revmatologiya
2024 #18 Issue 5 107 - 115 pp.

Glucocorticoids (GC) and immunosuppressants (IS) are traditional treatments for vasculitis associated with antineutrophil cytoplasmic antibodies (ANCA), often resulting in the development of infections, diabetes mellitus and other adverse events (AEs). The development of a steroid-sparing strategy using biologic disease-modifying antirheumatic drugs (bDMARDs, including rituximab, etc.) and synthetic targeted drugs (avacopan) has radically improved the course of the disease. Currently, there are increasing number of basic and clinical trials of numerous bDMARDs that effectively reduce the number of AEs associated with GC and IS. The steroid-sparing therapeutic strategy not only shows considerable efficacy, but also opens up new perspectives for the treatment of patients with ANCA-associated systemic vasculitis.

avacopan , genetically engineered biological drugs , glucocorticoids , immunosuppressants , rituximab , steroid-sparing therapy , vasculitis associated with antineutrophil cytoplasmic antibodies

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V.A. Nasonova Research Institute of Rheumatology, 34A, Kashirskoe Shosse, Moscow, 115522, Russian Federation
Kazakh National Medical University named after S.D. Asfendiyarov, 94, Tole bi Street, Almaty, 050012, Kazakhstan
Department of Rheumatology Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia, 2/1, Barrikadnaya Street, Build. 1, Moscow, 125993, Russian Federation

V.A. Nasonova Research Institute of Rheumatology
Kazakh National Medical University named after S.D. Asfendiyarov
Department of Rheumatology Russian Medical Academy of Continuing Professional Education

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