The investigation of physical and chemical properties of water solutions of polymers and their application in combination with drugs
Dzhakipbekov E.O. Sakibayeva S.A. Dzhakipbekova N.O. Sagitova G.F. Bekzhigitova K.A. Shingisbayeva Z.A.
January-March 2021Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma
Rasayan Journal of Chemistry
2021#14Issue 11 - 8 pp.
In this article are shown soft dosage forms (ointments) obtained based on polymer reagents. Water-soluble polymers are synthesized based on acryl-containing compounds. Aqueous solutions of polymeric reagents and their physical and chemical properties (viscosity and optical density) have been investigated. It was shown that polymers can be used for the transportation of drugs. The polymer macromolecule at pH = 3.5 is in a folded state. The macromolecule is unfolded with increasing pH. This leads to an increase in viscosity, the optical density does not change. The drugs are passed toxicological control. Based on toxicological investigate and analysis of the data obtained, it was concluded that the polymers have insignificant functional accumulation. Do not show skin-resorptive and allergic effects. The compatibility of polymers with antibiotics (levomycetin, levomycetin sodium succinate) was investigated. To establish the compatibility of copolymers with the antibiotics levomycetin, levomycetin sodium succinate and neomycin sulfate, it is necessary to identify the antimicrobial activity of antibiotics, which is determined by diffusion into agar. The properties of soft dosage forms (ointments) were sinvestigated using the agar diffusion method, it was shown that antibiotics are compatible in combination with the polymer reagent and their antimicrobial activity was revealed.
Drug , Levomycetin , Modifier , Ointment , Optical Density , Sodium , Viscosity
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M. Auezov South Kazakhstan University, Department of Oil Refining and Petrochemistry, Tauke Khan av. 5, Shymkent, Kazakhstan
M. Auezov South Kazakhstan University, Department of Chemistry and Fundamentals of Chemical Technology, Tauke Khan av. 5, Shymkent, Kazakhstan
M. Auezov South Kazakhstan University, Department of Ecology, Tauke Khan av. 5, Shymkent, Kazakhstan
M. Auezov South Kazakhstan University
M. Auezov South Kazakhstan University
M. Auezov South Kazakhstan University
10 лет помогаем публиковать статьи Международный издатель
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