Photodynamic Therapy Efficacy of the Human Papillomavirus-Related Cervical Lesions
Dushkin A. Grishacheva T. Afanasiev S. Dushkina I. Karaulov A. Biryukova E. Khangeldi A. Babayan K. Shanazarov N. Afanasiev M.
February 2026Multidisciplinary Digital Publishing Institute (MDPI)
Journal of Clinical Medicine
2026#15Issue 4
Background/Objectives: This study aims to fill certain knowledge gaps by assessing the clinical effectiveness of PDT in a large group of women with HPV-related cervical lesions and examining how different patient factors affect treatment results. Methods: A total of 811 women aged from 19 to 76 were retrospectively analyzed who were treated by PDT of HPV infection with atypical squamous cells and HPV-related cervical lesions. PDT was performed using chlorin e6-based systemic photosensitizers. Irradiation was carried out at 662 nm. The endocervical dose was 334 J/cm2, and the ectocervical dose was 291 J/cm2. Results: Overall HPV clearance was 91.1%, lesion remission was 95.3%, and complete response was 88.3%, with the highest complete response observed in the HSIL group compared with HPV-positive ASCs. Multivariable models showed that multiple HPV infection (especially >3 genotypes) and pregnancy history were associated with lower odds of complete response, while younger age (18–25 years) and TZ2 were associated with higher odds of complete response. Conclusions: PDT using chlorin e6-based photosensitizers demonstrated high clinical and virological effectiveness across HPV-related cervical abnormalities, including HSIL, supporting its role as an organ-preserving treatment option. Multiple HPV genotypes and pregnancy history may identify patients at increased risk of partial response and warrant closer follow-up or tailored treatment strategies.
cervical lesions , complete response , HPV clearance , lesion remission , photodynamic therapy
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Department of General Medicine No. 1, Moscow Clinical Science and Research Center 52, Moscow, 123182, Russian Federation
Center of the Laser Medicine, First Pavlov State Medical University, Saint Petersburg, 197022, Russian Federation
Department of Medical Biotechnology, G.N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, Federal Service for the Oversight of Consumer Protection and Welfare, Moscow, 125212, Russian Federation
Gynecology Department, Moscow City Hospital 67, Moscow, 123423, Russian Federation
Clinical Immunology and Allergology Department, I.M. Sechenov First Moscow State Medical University, Moscow, 119991, Russian Federation
Gynecology Department, NJSC “Astana Medical University”, Astana, 010000, Kazakhstan
Medical Faculty, Rostov State Medical University, Rostov-on-Don, 344022, Russian Federation
Medical Center Hospital of President’s Affairs Administration of the Republic of Kazakhstan, Astana, 010000, Kazakhstan
Department of General Medicine No. 1
Center of the Laser Medicine
Department of Medical Biotechnology
Gynecology Department
Clinical Immunology and Allergology Department
Gynecology Department
Medical Faculty
Medical Center Hospital of President’s Affairs Administration of the Republic of Kazakhstan
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