The high burden of pediatric cystic echinococcosis in Kazakhstan: epidemiological and clinical consequences
Doszhanova G. Colpani A. Duisenova A. De Vito A. Zholdybay Z. Juszkiewicz K. Brunetti E. Katarbayev A. Kaniyev S. Zhakenova Z. Manciulli T. Mustapayeva A.
1 December 2023Oxford University Press
Transactions of the Royal Society of Tropical Medicine and Hygiene
2023#117Issue 12875 - 877 pp.
Background: Cystic echinococcosis (CE) is attributable to Echinococcus granulosus metacestodes. Ultrasound examinations enable a stage-specific approach to CE management. However, this approach is not often applied in endemic areas, which include Kazakhstan. Methods: We collected clinical and ultrasound data on CE pediatric patients seen at a national referral surgical center in Almaty, Kazakhstan, during 2015-2020. Results: We included 49 patients, and 79 cysts that were all surgically treated. All but one patient carried active cysts (CE1-CE3 stages). Twenty-six (53.2%) did not receive albendazole postsurgery. Children with CE1 and CE3a cysts underwent surgery, while the use of albendazole and percutaneous drainage were advised upon by experts. Conclusions: A stage-specific approach to CE management in Kazakhstan is urgent, especially in the pediatric population. The rate of active cysts suggests continuing transmission of CE.
central Asia , children , clinical management , cystic echinococcosis , disease burden
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Department of Infectious and Tropical Diseases, Asfendyiarov Kazakh National Medical University, 94 Tole Bi Street, Almaty, 050012, Kazakhstan
Unit of Infectious Diseases, Department of Medicine Surgery and Pharmacy, University of Sassari, Sassari, 07100, Italy
Department of Visual Diagnostics, Asfendiyarov Kazakh National Medical University, 94 Tole Bi Street, Almaty, 050012, Kazakhstan
WHO-Collaborating Center for the Clinical Management of Cystic Echinoccocosis, San Matteo Hospital Foundation, Pavia, 27100, Italy
Department of Clinical-Surgical Diagnostic and Pediatric Sciences, University of Pavia, Pavia, 27100, Italy
Department of Children Infectious Diseases, Asfendiyarov Kazakh National Medical University, 94 Tole Bi Street, Almaty, 050012, Kazakhstan
Syzganov National Institute of Surgery, 62 Zheltoksan Street, Almaty, 050004, Kazakhstan
Department of Clinical and Experimental Medicine, University of Florence, Florence, 50121, Italy
Department of Infectious and Tropical Diseases
Unit of Infectious Diseases
Department of Visual Diagnostics
WHO-Collaborating Center for the Clinical Management of Cystic Echinoccocosis
Department of Clinical-Surgical Diagnostic and Pediatric Sciences
Department of Children Infectious Diseases
Syzganov National Institute of Surgery
Department of Clinical and Experimental Medicine
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