BIOLOGICAL ACTIVITY AND ALKALOID COMPOSITION OF Chelidonium majus L. GROWING AT THREE SITES IN THE EASTERN PART OF KUNGEY ALATAU RIDGE (KAZAKHSTAN)
Dostemessova A. Canpolat Ş. Kurmanbayeva M. Sadykova D. Canpolat E.Y. Ildız E. Izbastina K. İşlek C.
March 2025ACS Publisher
Applied Biological Research
2025#27Issue 180 - 93 pp.
Chelidonium majus L. (family Papaveraceae), widely known as greater celandine, is a valuable plant used in traditional medicine. The present study was aimed to compare the antioxidant and antimicrobial activities, as well as the alkaloid composition in tdifferent parts of C. majus collected from various locations in Kungei-Alatau region of Kazakhstan. The amount of total phenolic compounds and the antioxidant capability were determined by using Folin-Ciocalteu phenol reagent, radical (DPPH and ABTS) scavenging, and metal ion reducing (PFRAP) assays. Antimicrobial activity was evaluated by agar disc diffusion technique. The alkaloid composition was characterized by GC-MS. The root samples yielded the highest antioxidant and antimicrobial activity compared to the aerial parts. The root extracts yielded highest scavenging activity in DPPH (1745.37 ± 1.9 µmol TE mL-1), ABTS (917.97 ± 10.43 µmol TE mL-1), and PFRAP value (18.93 ± 0,14 mmol AAE mL-1) as well as exhibited highest phenolic content (2617.62 ±5.53 µg GAE mL-1). The root extracts also showed largest inhibition zone (33.0 ±0.82 mm) against Bacillus subtilis. A total of 26 alkaloids, including chelidonine, demethylchelerythrine, dihydro-chelerythrine, dihydrochelirubine, and dihydrosanguinarine, were identified. The results indicated that the roots of C. majus possess more biologically active component than its other plant parts.
Alkaloids , antimicrobial activity , antioxidant , Chelidonium majus , GC-MS
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Al-Farabi Kazakh National University, Astana, 010 000, Kazakhstan
Central Research Laboratory Center, Niğde Ömer Halisdemir University, Hidge, 51240, Turkey
Kazakh National Womens Pedagogical University, Almaty, 050 000, Kazakhstan
Department of Biotechnology, Faculty of Science, Niğde Ömer Halisdemir University, Hidge, 51240, Turkey
S. Seifullin Kazakh Agro Technical Research University, Astana, 010 000, Kazakhstan
Al-Farabi Kazakh National University
Central Research Laboratory Center
Kazakh National Womens Pedagogical University
Department of Biotechnology
S. Seifullin Kazakh Agro Technical Research University
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