The Influence of Disease Duration in Pharmacoresistant Focal Epilepsy and Type of Antiepileptic Therapy on Intraoperative Infusion Therapy Parameters
Dossov M. Seitenov S. Bekenova N. Kuatbay G.
2 November 2025National Scientific Medical Center
Journal of Clinical Medicine of Kazakhstan
2025#22Issue 64 - 9 pp.
Objective: To evaluate the impact of disease duration of pharmacoresistant focal epilepsy and type of antiepileptic therapy on intraoperative infusion therapy parameters. Materials and Methods: A retrospective cohort study was conducted involving 102 patients (2019–2024) who underwent neurosurgical intervention for pharmacoresistant focal epilepsy. Patients were stratified by disease duration (≤15 years and >15 years) and therapy type (monotherapy and polytherapy). The following parameters were evaluated: infusion volume, infusion therapy composition, fluid balance, urine output, blood loss, extubation time, and length of stay in the intensive care unit. Results: Polytherapy was associated with significantly higher fluid balance and greater crystalloid volume compared to monotherapy (p<0.05). Prolonged disease course (>15 years) was accompanied by a tendency toward increased fluid balance and significantly prolonged time to extubation (p<0.05). Hemodynamic parameters remained stable across all groups. Conclusion: The type of antiepileptic therapy and disease duration are significant factors influencing infusion therapy volume. A personalized approach to infusion management in patients with pharmacoresistant epilepsy may enhance safety and improve outcomes.
epilepsy surgery , neurosurgery , perioperative fluid management
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Anesthesiology and ICU Department, Medical Center Hospital of the President’s Affairs Administration of the Republic of Kazakhstan, Astana, Kazakhstan
Deputy head of the medical center, Medical Center Hospital of President’s Affairs Administration of the Republic of Kazakhstan, Astana, Kazakhstan
Department of Science, Medical Center Hospital of the President’s Affairs Administration of the Republic of Kazakhstan, Astana, Kazakhstan
Internal Medicine Department, Medical Center Hospital of the President’s Affairs Administration of the Republic of Kazakhstan, Astana, Kazakhstan
Anesthesiology and ICU Department
Deputy head of the medical center
Department of Science
Internal Medicine Department
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