The relation between vitamin D and the adolescents’ mid-luteal estradiol and progesterone

Donayeva A. Amanzholkyzy A. Abdelazim I.A. Saparbayev S. Nurgaliyeva R. Kaldybayeva A. Zhexenova A. Stankevicius E. Khamidullina Z. Gubasheva G. Ayaganov D. Samaha I.I.
2023 Verduci Editore s.r.l

European Review for Medical and Pharmacological Sciences
2023 #27 Issue 14 6792 - 6799 pp.

OBJECTIVE: The aim of this study was to detect the effect of vitamin D (Vit. D) intake on the mid-luteal estradiol (E₂), and progesterone (P), and the relation between vit. D, and the adolescents’ mid-luteal E₂, and P. PATIENTS AND METHODS: Eighty-five (85) adolescents were recruited for this cohort study after obtaining informed consent. After a detailed history and clinical examination, the body mass index (BMI) of the studied participants was calculated, followed by pelvic sonography to exclude any pelvic pathology. Participants’ blood samples were collected on days 21-22 of the menstrual cycle (mid-luteal) to measure the thyrotropin (TSH) (i.e., to exclude hypothyroidism), prolactin (i.e., to exclude hyperprolactinemia), glycosylated hemoglobin (HbA1C), (i.e., to exclude diabetes), E₂, P, and 25(OH)D. Participants received 50,000 IU of vit. D weekly for two months, and on the 3^rd month, the mid-luteal E₂, P, and 25(OH)D were measured. The mid-luteal E₂, P, and 25(OH)D were compared before and after the vit. D intake to detect the effect of vit. D intake (50,000 IU weekly for 2 months) on the mid-luteal E₂ and P (primary outcome). Additionally, the relations between vit. D and the adolescents’ mid-luteal E₂ and P were detected as secondary outcomes using the correlation analysis (Pearson’s correlation). RESULTS: The mid-luteal E₂ and P statistically decreased from 109.3±15.7 pg/mL and 9.8±1.01 ng/mL, respectively to 40.7±10.52 pg/ mL, and 5.2±0.73 ng/mL, respectively, after vit. D intake (p=0.00015; 95% CI: 64.5, 68.6, 72.7, and p=0.0016; 95% CI: 4.3, 4.6, 4.87, respectively). Significant negative correlations between the 25(OH)D, and both the mid-luteal E₂ (r -0.661; p<0.00001), and P (r -0.521; p<0.00001) were detected in this study. CONCLUSIONS: The mid-luteal E₂ and P statistically decreased after vit. D intake (50,000 IU of vit. D weekly for 2 months). Significant negative correlations between the 25(OH)D, and both the mid-luteal E₂ and P were detected in this study. The relation between vit. D and ovarian steroids, and the effect of vit. D intake on ovarian steroids need further larger studies.

Adolescents , Estradiol , Mid-Luteal , Progesterone , Vit. D , Vitamin D

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Department of Normal Physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Department of Pathological Physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Normal Physiology, Pharmacology and Vascular Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania
Department of Obstetrics and Gynecology No. 1, Astana Medical University, Astana, Kazakhstan
Department of Obstetrics and Gynecology No. 2, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Neurology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Obstetrics and Gynecology, Faculty of Medicine, Helwan University, Cairo, Egypt

Department of Normal Physiology
Department of Obstetrics and Gynecology
Department of Pathological Physiology
Department of Normal Physiology
Department of Obstetrics and Gynecology No. 1
Department of Obstetrics and Gynecology No. 2
Department of Neurology
Department of Obstetrics and Gynecology

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