The effect of vitamin D on adolescents’ primary dysmenorrhea
Donayeva A. Amanzholkyzy A. Abdelazim I. Kurmangazin M. Khamidullina Z. Kurmanalina M. Sumanova A. Shabanbayeva Z. Baubekov Z. Bissaliyev B. Gubasheva G. Samaha I.
2023Carol Davila University Press
Journal of Medicine and Life
2023#16Issue 111658 - 1662 pp.
Vitamin D receptor (VDR) expression in the female reproductive tract explains the regulatory role of vitamin D on inflammatory cytokine and prostaglandin (PGD) synthesis. This study aimed to evaluate the effect of vitamin D on adolescents’ primary dysmenorrhea and the relationship between Vit. D and adolescents’ primary dysmenorrhea. Eighty-five adolescents were included in the current study. After a detailed evaluation, pelvic sonography was per-formed for all participants to rule out any pelvic pathology. Blood samples were collected to measure thyroid stim-ulating hormone (TSH), prolactin, glycosylated hemoglobin (HbA1C), and 25-hydroxyvitamin D (25[OH]D). Participants were administered vitamin D (50,000 IU weekly for five months), and their dysmenorrhea symptoms were evaluated before and after this period using the Visual Analog Scale (VAS) and the Verbal Multidimensional Scoring (VMS). The mean VAS and VMS scores of dysmenorrhea statistically decreased from 8.7±0.91 and 2.65±0.93 to 4.8±0.75 and 0.80±0.75, respectively, after vitamin D intake (p=0.03 and 0.025, respectively). Significant negative as-sociations between 25(OH)D and VAS (R =-0.886; p<0.00001) and VMS of dysmenorrhea (R =-0.885; p<0.00001) were detected in this study. Vit. D could be a useful therapeutic option to reduce the severity of primary dysmenor-rhea and could limit the use of non-steroidal anti-inflammatory drugs.
adolescents , dysmenorrhea , vitamin D
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Department of Normal Physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
, Astana Medical University, Astana, Kazakhstan
Department of Therapeutic and Orthopedic Dentistry, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Pediatric Surgery, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Obstetrics and Gynecology, Faculty of Medicine, Helwan University, Cairo, Egypt
Department of Normal Physiology
Department of Obstetrics and Gynecology
, Astana Medical University, Astana, Kazakhstan
Department of Therapeutic and Orthopedic Dentistry
Department of Pediatric Surgery
, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Obstetrics and Gynecology
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