Relationship between vitamin D and adolescents’ hypothyroidism – a cross-sectional study

Donayeva A. Kulzhanova D. Amanzholkyzy A. Abdelazim I.A. Abilov T. Baubekov Z. Samaha I.I.
2023 Termedia Publishing House Ltd.

Przeglad Menopauzalny
2023 #22 Issue 4 186 - 190 pp.

Introduction: To detect the relationship between 25(OH)D and hypothyroidism in adolescents. Material and methods: A total of 180 adolescents were included in the current study, which was conducted in West Kazakhstan (Aktobe) over 2 years. After thorough evaluation, blood samples were collected from the studied participants to measure the thyroid stimulating hormone (TSH), free thyroxine (T4), prolactin, glycosylated haemoglobin, and 25(OH)D. Participants were classified into a 25(OH)D-deficient group (study group) and controls. MedCalc and correlation analysis (Pearson’s correlation) were used to detect the odds of hypothyroidism and the relationship between 25(OH)D and adolescents’ hypothyroidism, respectively. Results: Thyroid-stimulating hormone was statistically higher in the 25(OH)D-deficient group than in the normal controls (3.71 ±1.4 mIU/ml vs. 2.67 ±0.99) (p = 0.0006), and the free T4 was statistically lower in the 25(OH)D-deficient group than in normal controls (1.4 ±0.56 ng/ml vs. 1.5 ±0.4) (p = 0.0008). The 25(OH)D deficient group had higher odds of subclinical (OR 4.89; p = 0.016), and clinical hypothyroidism (OR 4.3; p = 0.013) compared to controls. A significant negative correlation between the 25(OH)D and TSH (r = –0.793; p < 0.00001), and a significant positive correlation between the 25(OH)D and free T4 (r 0.55; p < 0.00001) were detected in this study. Conclusions: The thyroid-stimulating hormone was statistically higher and the free T4 was statistically lower in the 25(OH)D-deficient group than in normal controls. The 25(OH)D-deficient group had higher odds of both subclinical and clinical hypothyroidism compared to controls. A significant negative correlation between the 25(OH)D and TSH, and a significant positive correlation between the 25(OH)D and the free T4 were detected in this study.

25(OH)D , adolescents , hypothyroidism , vitamin D

Text of the article Перейти на текст статьи

Department of Normal Physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Obstetrics and Gynaecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Department of Pediatric Surgery, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Obstetrics and Gynecology, Faculty of Medicine, Helwan University, Cairo, Egypt

Department of Normal Physiology
Department of Obstetrics and Gynaecology
Department of Pediatric Surgery
Department of Obstetrics and Gynecology

10 лет помогаем публиковать статьи Международный издатель

Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026