Polycaprolactone-Mxene nanofibrous scaffolds for tissue engineering
Diedkova K. Pogrebnjak A.D. Kyrylenko S. Smyrnova K. Buranich V.V. Horodek P. Zukowski P. Koltunowicz T.N. Galaszkiewicz P. Makashina K. Bondariev V. Sahul M. Caplovicova M. Husak Y. Simka W. Korniienko V. Stolarczyk A. Blacha-Grzechnik A. Balitskyi V. Zahorodna V. Baginskiy I. Riekstina U. Gogotsi O. Gogotsi Y. Pogorielov M.
22 March 2023American Chemical Society
ACS Applied Materials and Interfaces
2023#15Issue 1114033 - 14047 pp.
New conductive materials for tissue engineering are needed for the development of regenerative strategies for nervous, muscular, and heart tissues. Polycaprolactone (PCL) is used to obtain biocompatible and biodegradable nanofiber scaffolds by electrospinning. MXenes, a large class of biocompatible 2D nanomaterials, can make polymer scaffolds conductive and hydrophilic. However, an understanding of how their physical properties affect potential biomedical applications is still lacking. We immobilized Ti3C2Tx MXene in several layers on the electrospun PCL membranes and used positron annihilation analysis combined with other techniques to elucidate the defect structure and porosity of nanofiber scaffolds. The polymer base was characterized by the presence of nanopores. The MXene surface layers had abundant vacancies at temperatures of 305- 355 K, and a voltage resonance at 8 × 104 Hz with the relaxation time of 6.5 × 106 s was found in the 20-355 K temperature interval. The appearance of a long-lived component of the positron lifetime was observed, which was dependent on the annealing temperature. The study of conductivity of the composite scaffolds in a wide temperature range, including its inductive and capacity components, showed the possibility of the use of MXene-coated PCL membranes as conductive biomaterials. The electronic structure of MXene and the defects formed in its layers were correlated with the biological properties of the scaffolds in vitro and in bacterial adhesion tests. Double and triple MXene coatings formed an appropriate environment for cell attachment and proliferation with mild antibacterial effects. A combination of structural, chemical, electrical, and biological properties of the PCL-MXene composite demonstrated its advantage over the existing conductive scaffolds for tissue engineering.
Conductive biomaterials , Electrospinning , MXene , Porous scaffold , Tissue engineering
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Sumy State University, Sumy, 40007, Ukraine
University of Latvia, Riga, LV-1004, Latvia
Department of Motor Vehicles, Lublin University of Technology, Lublin, 20-618, Poland
Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Institute of Materials Science, Faculty of Materials Science and Technology, Slovak University of Technology, Trnava, 917 24, Slovakia
Henryk Niewodniczanski Institute of Nuclear Physics of the Polish Academy of Sciences, Krakow, 31-342, Poland
Department of Electrical Devices and High Voltage Technology, Lublin University of Technology, Lublin, 20-618, Poland
East-Kazakhstan State Technical University, Ust-Kamenogorsk, 070000, Kazakhstan
Centre for Nanodiagnostics of Materials, Slovak University of Technology in Bratislava, Bratislava, 812 43, Slovakia
Faculty of Chemistry, Silesian University of Technology, Gliwice, 44-100, Poland
A. J. Drexel Nanomaterials Institute, Department of Materials Science and Engineering, Drexel University, Philadelphia, 19104, PA, United States
Sumy State University
University of Latvia
Department of Motor Vehicles
Al-Farabi Kazakh National University
Institute of Materials Science
Henryk Niewodniczanski Institute of Nuclear Physics of the Polish Academy of Sciences
Department of Electrical Devices and High Voltage Technology
East-Kazakhstan State Technical University
Centre for Nanodiagnostics of Materials
Faculty of Chemistry
A. J. Drexel Nanomaterials Institute
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