Sesquiterpenoid lactones as potential anti-cancer agents: an update on molecular mechanisms and recent studies
Dhyani P. Sati P. Sharma E. Attri D.C. Bahukhandi A. Tynybekov B. Szopa A. Sharifi-Rad J. Calina D. Suleria H.A.R. Cho W.C.
December 2022BioMed Central Ltd
Cancer Cell International
2022#22Issue 1
Plants-based natural compounds are well-identified and recognized chemoprotective agents that can be used for primary and secondary cancer prevention, as they have proven efficacy and fewer side effects. In todays scenario, when cancer cases rapidly increase in developed and developing countries, the anti-cancerous plant-based compounds become highly imperative. Among others, the Asteraceae (Compositae) familys plants are rich in sesquiterpenoid lactones, a subclass of terpenoids with wide structural diversity, and offer unique anti-cancerous effects. These plants are utilized in folk medicine against numerous diseases worldwide. However, these plants are now a part of the modern medical system, with their sesquiterpenoid lactones researched extensively to find more effective and efficient cancer drug regimens. Given the evolving importance of sesquiterpenoid lactones for cancer research, this review comprehensively covers different domains in a spectrum of sesquiterpenoid lactones viz (i) Guaianolides (ii) Pseudoguaianolide (iii) Eudesmanolide (iv) Melampodinin A and (v) Germacrene, from important plants such as Cynara scolymus (globe artichoke), Arnica montana (wolf weeds), Spilanthes acmella, Taraxacum officinale, Melampodium, Solidago spp. The review, therefore, envisages being a helpful resource for the growth of plant-based anti-cancerous drug development.
Anti-tumor , Apoptosis , Cancer , Complementary medicine , Molecular mechanisms , Sesquiterpenoid lactones , Signaling pathway
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Department of Biotechnology, Kumaun University, Uttarakhand, Bhimtal, 263 136, India
Graphic Era University, Uttarakhand, Dehradun, 248 001, India
Department of Molecular Biology and Biochemistry, Guru Nanak Dev University, Punjab, Amritsar, 143 005, India
High Altitude Plant Physiology Research Centre (HAPPRC), HNB Garhwal University, Uttarakhand, Srinagar Garhwal, 246 174, India
G.B. Pant National Institute of Himalayan Environment, Kosi-Katarmal, Uttarakhand, Almora, 263 643, India
Department of Biodiversity of Bioresources, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Department of Pharmaceutical Botany, Medical College, Jagiellonian University, Medyczna 9, Kraków, 30-688, Poland
Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, 200349, Romania
School of Agriculture and Food, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, 3010, VIC, Australia
Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong
Department of Biotechnology
Graphic Era University
Department of Molecular Biology and Biochemistry
High Altitude Plant Physiology Research Centre (HAPPRC)
G.B. Pant National Institute of Himalayan Environment
Department of Biodiversity of Bioresources
Department of Pharmaceutical Botany
Facultad de Medicina
Department of Clinical Pharmacy
School of Agriculture and Food
Department of Clinical Oncology
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