Peptide-conjugated nanoparticles for targeted photodynamic therapy
Dhaini B. Kenzhebayeva B. Ben-Mihoub A. Gries M. Acherar S. Baros F. Thomas N. Daouk J. Schohn H. Hamieh T. Frochot C.
2 September 2021De Gruyter Open Ltd
Nanophotonics
2021#10Issue 123089 - 3134 pp.
Cancer is the second leading cause of death worldwide after cardiovascular disease. Depending on the type and the location of the tumor, several cancer treatments are implemented. Among these, the three most conventional therapies are surgery, radiotherapy and chemotherapy. However, there are other therapeutic approaches such as photodynamic therapy (PDT). PDT relies on the combined action of light, a photoactivable molecule called photosensitizer (PS) and molecular oxygen. Most of the PSs used for clinical applications are not cancer-cell specific. One of the solutions to overcome this problem is the use of nanoparticles (NPs) to induce a passive targeting. It is also possible to graft a vector onto the NPs to specifically target membrane receptors overexpressed in the tumor cells or neovessels surrounding the tumor. In this review, we focus on the NPs loaded with PSs and coupled to peptides for targeted PDT. We described nanosystems that targeted Neuropilin-1 (NRP-1), αvβ3 integrins, nucleolin membrane receptor, epidermal growth factor (EGF) receptor, protein-glutamine-gamma-glutamyltransferase (TGM2), p32, transferrin, PD-1, and mitochondrial membrane. The use of a cell absorbing-peptide is also described.
cancer , nanoparticle , peptide , photodynamic therapy , photosensitizer , targeting
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Reactions and Chemical Engineering Laboratory, Université de Lorraine, LRGP-CNRS, Nancy, F-54000, France
Laboratory of Materials, Catalysis Environment and Analytical Methods Laboratory (MCEMA), Faculty of Sciences, Lebanese University, Hadath, Lebanon
Laboratory of Macromolecular Physical Chemistry, Université de Lorraine, LCPM-CNRS, Nancy, F-54000, France
Department of Chemical and Biochemical Engineering, University of Satbayev, Almaty, Kazakhstan
Department of Biology, Signals and Systems in Cancer and Neuroscience, Université de Lorraine, CRAN-CNRS, Nancy, F-54000, France
Faculty of Science and Engineering, Maastricht University, P.O. Box 616, Maastricht, 6200 MD, Netherlands
Reactions and Chemical Engineering Laboratory
Laboratory of Materials
Laboratory of Macromolecular Physical Chemistry
Department of Chemical and Biochemical Engineering
Department of Biology
Faculty of Science and Engineering
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