Studying the wound healing property of biologically and chemically synthesized gold nanoparticles through scratch assay and neural network modeling
Desai A.S. Ashok A. Wagle S.A. Bhagat N. Ashirova Z. Abdrassulova Z.T. Abdolla N. Mukazhanova Z. Ydyrys A. Seilkhan A.
February 2025Springer Science and Business Media B.V.
Advanced Composites and Hybrid Materials
2025#8Issue 1
Gold nanoparticles (Au NPs) are commonly used as anti-haemorrhagic and antiseptic agents. Thus, their cytotoxicity should be studied before application. In this study, the Au NPs were synthesized using biological and chemical routes, and the samples were named as AU-BT and AU-C, respectively. The AU-BT were synthesized using three different extracts, i.e., turmeric, aloe-vera, and a mixture of turmeric aloe-vera. The cytotoxicity was studied using scratch assay on HEK-293 cell lines. The number of scratch assays was increased to validate the experimental wound healing results. Finally, a neural networking modeling was performed to predict the results of provided data in terms of the sample toxicity by healing the wound. The experimental results and the neural networking confirmed that the turmeric-derived Au NPs were the best among all the synthesized samples. Moreover, integrating metal NPs in wound healing studies introduces exciting possibilities for enhanced imaging and therapeutic interventions. The combination of advanced image analysis through models like AlexNet and the novel use of nanoparticles opens doors to improved wound care and a deeper understanding of the healing process.
Artemisia schrenkiana , Gold nanoparticles , HEK-293 cell lines , Neural networking , Scratch assay
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Department of Applied Science, Samundra Institute of Maritime Studies, Lonavala, Maharashtra, Pune, 410405, India
Department of Applied Science, Symbiosis Institute of Technology, Symbiosis International (Deemed) University, Maharashtra, Pune, 412115, India
Department of Artificial Intelligence & Machine Learning, Symbiosis Institute of Technology, Symbiosis International (Deemed) University, Maharashtra, Pune, 412115, India
Biomedical Research Centre, Al-Farabi Kazakh National University, Al-Farabi Ave. 71, Almaty, 050040, Kazakhstan
Bolashaq Centre for International Programs, 70 Syganak Str, Astana, 010000, Kazakhstan
Laboratory of Molecular Immunology and Immunobiotechnology, M.A. Aitkhozhin’s, Institute of Molecular Biology and Biochemistry, Almaty, Kazakhstan
Higher School of IT and Natural Sciences, Sarsen Amanzholov East Kazakhstan University, Ust-Kamenogorsk, 070010, Kazakhstan
Educational Program, Geography, Environment and Service Sector, Abai Kazakh National Pedagogical University, Almaty, Kazakhstan
St. Mira’s College for Girls, St. Mira’s College, Pune, India
Department of Applied Science
Department of Applied Science
Department of Artificial Intelligence & Machine Learning
Biomedical Research Centre
Bolashaq Centre for International Programs
Laboratory of Molecular Immunology and Immunobiotechnology
Higher School of IT and Natural Sciences
Educational Program
St. Mira’s College for Girls
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