Therapeutic novelties in acute heart failure and practical perspectives
Deniau B. Asakage A. Takagi K. Gayat E. Mebazaa A. Rakisheva A.
April 2025Elsevier Masson s.r.l.
Anaesthesia Critical Care and Pain Medicine
2025#44Issue 2
Acute Heart Failure (AHF) is a leading cause of death and represents the most frequent cause of unplanned hospital admission in patients older than 65 years. Since the past decade, several randomized clinical trials have highlighted the importance and pivotal role of certain therapeutics, including decongestion by the combination of loop diuretics, the need for rapid goal-directed medical therapies implementation before discharge, risk stratification, and early follow-up after discharge therapies. Cardiogenic shock, defined as sustained hypotension with tissue hypoperfusion due to low cardiac output and congestion, is the most severe form of AHF and mainly occurs after acute myocardial infarction, which can progress to multiple organ failure. Although its prevalence is relatively low, cardiogenic shock complicates 12% of acute myocardial infarction. After a brief summary of the epidemiology of AHF and cardiogenic shock, followed by key pathophysiological points, we detailed current treatments in AHF and cardiogenic shock what every anaesthesiologist and intensivist needs to know, based on the latest guidelines and randomized clinical trials published in recent years.
Acute heart failure , AHA/ACC/HFSA guidelines , Decongestion therapy , ESC guidelines , Goal directed medical therapy
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Department of Anesthesia, Burn and Critical Care, University Hospitals Saint-Louis - Lariboisière, AP-HP, Paris, France
UMR-S 942, INSERM, MASCOT, Paris University, Paris, France
Paris Cité University, Paris, France
FHU PROMICE, Paris, France
INI CRCT Network, Nancy, France
Department of Emergency Medicine and Critical Care, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan
Momentum Research Inc, Durham, NC, United States
City Cardiological Center, Almaty, Kazakhstan
Department of Anesthesia
UMR-S 942
Paris Cité University
FHU PROMICE
INI CRCT Network
Department of Emergency Medicine and Critical Care
Momentum Research Inc
City Cardiological Center
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