Preventive effects of Capparis Spinose extract on experimental periodontitis in rats: a histopathological and biochemical study

Dds H.G. Dds H.Ö. İnan Z.D.Ş.
2023 Cellular and Molecular Biology Association

Cellular and Molecular Biology
2023 #69 Issue 8 132 - 136 pp.

This study aimed to assess the effectiveness of Capparis Spinose (CS) in preventing the initiation and progression of experimental periodontitis and to evaluate the effect of its on systemic oxidative stress in rats by experimental periodontitis model. Twenty-four male rats were equally divided into; Ligatured (L), non-ligatured (NL), and Ligatured with CS (11 days/day per 20 mg/kg) (LC) groups. Experimental periodontitis was induced with the silk suture technic. Alveolar bone loss was examined, and total antioxidant capacity(TAOC), total oxidant status(TOS), and oxidative stress index(OSI) were analyzed in rat serum. Although; alveolar bone loss showed statistically significant lower values in the LC group compared to L (p < 0.05), not NL. In the LC group, osteoclast and osteoblast numbers were statistically significant compared to L, but there were no statistical differences between LC and NL. Serum TAOC levels were significantly lower in group L compared to others and also LC group showed significant differences from NL. TOS and OSI levels were significantly higher in group L than in other groups. Within the limitation of the present study, it can be said that the destruction via local inflammation that may occur after the experimental periodontitis can be prevented by using CS. Copyright:

anti-inflammatory therapy , Capparis Spinose , Experimental periodontitis , oxidative stress

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Department of Surgery and Pediatric Dentistry, Faculty of Dentistry, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkestan, Kazakhstan
Department of Periodontology, Faculty of Dentistry, University of Eskişehir Osmangazi, Eskişehir, Turkey
Medicine Faculty, Histology&Embryology Department, Sivas Cumhuriyet University, Sivas, Turkey
Department of Medical Biochemistry, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey

Department of Surgery and Pediatric Dentistry
Department of Periodontology
Medicine Faculty
Department of Medical Biochemistry

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