Mesenchymal stem cell alongside exosomes as a novel cell-based therapy for COVID-19: A review study
Dauletova M. Hafsan H. Mahhengam N. Zekiy A.O. Ahmadi M. Siahmansouri H.
May 2021Academic Press Inc.
Clinical Immunology
2021#226
In the past year, an emerging disease called Coronavirus disease 2019 (COVID-19), caused by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been discovered in Wuhan, China, which has become a worrying pandemic and has challenged the world health system and economy. SARS-CoV-2 enters the host cell through a specific receptor (Angiotensin-converting enzyme 2) expressed on epithelial cells of various tissues. The virus, by inducing cell apoptosis and production of pro-inflammatory cytokines, generates as cytokine storm, which is the major cause of mortality in the patients. This type of response, along with responses by other immune cell, such as alveolar macrophages and neutrophils causes extensive damage to infected tissue. Newly, a novel cell-based therapy by Mesenchymal stem cell (MSC) as well as by their exosomes has been developed for treatment of COVID-19 that yielded promising outcomes. In this review study, we discuss the characteristics and benefits of MSCs therapy as well as MSC-secreted exosome therapy in treatment of COVID-19 patients.
Coronavirus disease 2019 , Exosome , Mesenchymal stem cell , Severe acute respiratory syndrome coronavirus 2 , Treatment
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Department of Propaedeutics and Internal Medicine, Akhmet Yassawi Internationl Kazakh-Turkish University, Turkistan, Kazakhstan
Department of Biology, Faculty of Science and Technology, Universitas Islam Negeri Alauddin Makassar, South Sulawesi, Indonesia
Faculty of General Medicine, Belarusian State Medical University, Minsk, Belarus
Department of Prosthetic Dentistry, Sechenov First Moscow State Medical University, Moscow, Russian Federation
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Propaedeutics and Internal Medicine
Department of Biology
Faculty of General Medicine
Department of Prosthetic Dentistry
Stem Cell Research Center
Department of Immunology
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