Nanofibrous biologically soluble scaffolds as an effective drug delivery system
Daulbayev C. Sultanov F. Aldasheva M. Abdybekova A. Bakbolat B. Shams M. Chekiyeva A. Mansurov Z.
2021Academie des sciences
Comptes Rendus Chimie
2021#24Issue 11 - 9 pp.
In this article, the synthesis of biocompatible fibrous scaffolds with antimicrobial properties based on polycaprolactone/hydroxyapatite/amoxicillin and study of their surface morphology, antimicrobial effect, and drug release are discussed. Hydroxyapatite (1-2_m, 97%) synthesized from biologically waste material (eggshell) was added to the composite scaffolds as a bone-replacement material. The scaffolds antimicrobial properties were evaluated against S. aureus and E. faecalis. The scaffolds possessed a sustained drug release from the scaffolds amounted to about 94% of the antibiotics total weight over a 4-week observation period. Agar diffusion confirmed the antimicrobial properties of the scaffolds against specific bacteria.
Biologically soluble scaffolds , Drugs , Electrospinning , Fibers , Hydroxyapatite
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aL-Farabi Kazakh National University, Almaty, 050038, Kazakhstan
Institute of Combustion Problems, Almaty, 050012, Kazakhstan
S.D. Asfendiyarov Kazakh NationalMedical University, Almaty, 050012, Kazakhstan
KazakhMedical University of Continuing Education, Almaty, 050040, Kazakhstan
K.I. Satbayev Kazakh National Research Technical University, Almaty, 050013, Kazakhstan
aL-Farabi Kazakh National University
Institute of Combustion Problems
S.D. Asfendiyarov Kazakh NationalMedical University
KazakhMedical University of Continuing Education
K.I. Satbayev Kazakh National Research Technical University
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