Effect of graphene oxide/hydroxyapatite nanocomposite on osteogenic differentiation and antimicrobial activity
Daulbayev C. Sultanov F. Korobeinyk A.V. Yeleuov M. Taurbekov A. Bakbolat B. Umirzakov A. Baimenov A. Daulbayev O.
February 2022Elsevier B.V.
Surfaces and Interfaces
2022#28
This paper presents the fabrication and characterization of electrospun graphene oxide/calcium hydroxyapatite/polycaprolactone composite. Polycaprolactone is well-known for its excellent medical property and chemo-resistance. On the other hand graphene oxide (GO) and calcium hydroxyapatite (HAp) are both known for their superior biocompatibility, high mechanical properties, considerable electrical and thermal conductivity. Under current research GO and HAp were synthesized from an abundant bio-wastes material. As-prepared GO/HAp composite was dispersed in biodegradable polymer – polycaprolactone (PCL) in order to device a composite scaffold with the purpose to enhance osteogenic differentiation of osteoblasts for potential medical application. Synthesised composite was characterised using various chemo-physical methods. Biocompatibility was tested in the cell proliferation assay with preosteoblasts MC3T3-E1 cell line in order to identify any cytotoxic effect caused by its compounds. The bacteriostatic effect of GO was assessed using Staphylococcus aureus and Escherichia coli bacterial strains. Obtained GO/HAp/PCL composite scaffold can serve as a biologically compatible matrix for potential bone tissue regeneration with antimicrobial effect; provides an excellent biological compatibility for prospective application in medicine and clinical dentistry.
Antimicrobial activity , Electrospinning , Graphene oxide , Hydroxyapatite , Osteogenic differentiation
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Al Farabi Kazakh National University, 172 Bogenbay batyr str, Almaty, Kazakhstan
Institute of Combustion Problems, Almaty, Kazakhstan
Satbayev Kazakh National University, Almaty, Kazakhstan
National Laboratory Astana, Nazarbayev University, Nur-Sultan, Kazakhstan
O.O. Chuiko Institute of Surface Chemistry of NAS of Ukraine, Kyiv, Ukraine
Joint Institute for Nuclear Research, Dubna, Russian Federation
Institute of Nuclear Physics, Almaty, Kazakhstan
Al Farabi Kazakh National University
Institute of Combustion Problems
Satbayev Kazakh National University
National Laboratory Astana
O.O. Chuiko Institute of Surface Chemistry of NAS of Ukraine
Joint Institute for Nuclear Research
Institute of Nuclear Physics
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