Global Research Trends on Endothelial Glycocalyx in Sepsis: A Bibliometric Analysis
Daniyarova K.R. Sarkulova Z.N. Tamadon A. Tokshilykova A.B. Sarkulov M.N. Kalieva B.M. Mussin N.M. Sharoffidin R.S.
2026John Wiley and Sons Ltd
BioMed Research International
2026#2026Issue 1
Background: Sepsis remains a major global health challenge, with glycocalyx dysfunction playing an important role in its pathogenesis. Recent research highlights EG degradation as a key contributor to vascular permeability, inflammation, and organ failure. Despite growing interest, a comprehensive bibliometric analysis of global research trends on EG in sepsis is lacking. Methods: We conducted a bibliometric analysis using data from Web of Science and Scopus (2005–2025). Inclusion criteria were original English-language research articles. Bibliometrix R-package was employed to analyze publication trends, citation metrics, collaboration networks, and keyword co-occurrence. Results: Among 217 publications, research output increased 13-fold (2005–2023), with Shock and Critical Care as leading journals. The United States, Japan, and Australia were top contributors, with strong international collaborations. Key themes included EG biomarkers, microcirculatory dysfunction, and therapeutic strategies. Emerging trends involved COVID-19–associated EG injury and novel imaging techniques. Conclusion: This study maps the evolution of EG research in sepsis, highlighting exponential growth, key contributors, and thematic shifts. Future directions include validating EG biomarkers, developing targeted therapies, and enhancing global research equity. Copyright
bibliometrics , glycocalyx , microcirculation , sepsis , syndecan-1
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Department of Anesthesiology and Reanimatology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Natural Sciences, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Surgical Diseases No.2 With a Course in Urology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Surgery No. 2, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Pharmaceutical Technology, Avicenna Tajik State Medical University, Dushanbe, Tajikistan
Department of Anesthesiology and Reanimatology
Department of Natural Sciences
Department of Surgical Diseases No.2 With a Course in Urology
Department of Surgery No. 2
Department of Pharmaceutical Technology
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