THERAPY OF PRESSURE SORES VIA ACTIVATION OF REGENERATIVE PROCESSED IN TISSUES BY LOW-TEMPERATURE GLOW-TYPE PLASMA DISCHARGES OF GLOW TYPE
Danileiko Y.K. Lukanin V.I. Altukhov E.L. Yakovlev A.A. Osmanov E.G. Kogan E.A. Shulutko A.M. Simakin A.V. Baimler I.V. Serov D.A. Astashev M.E. Sagyndykov U.Z. Belov S.V.
September 2022Lobachevsky State University of Nizhny Novgorod
Opera Medica et Physiologica
2022#9Issue 315 - 30 pp.
Pressure sores remain an important clinical problem with significant socioeconomic implications. The pressure sores treatment via reparative processes activation in tissues by low-temperature plasma discharges was studied in the present work. Low-temperature plasma discharges were initiated by high-frequency 0.11, 2.64, 6.78, and 13.56 MHz current. It is shown that the optimal current frequency for the generation of the cold plasma is 6.78 MHz. This current frequency was used in clinical studies of pressure sores treatment with cold plasma discharges of the glow type. The efficiency of treatment was evaluated by analysis of histological samples, histochemical and bacteriological methods. Low-temperature plasma discharge treatment improved the dynamic of pressure sore healing, activated reparative processes in injured tissues, and decreased bacteria numbers in a wound. The most pronounced effect was observed after 14-21 days. The low-temperature plasma discharges accelerated pressure sores healing from 14 to 16% compared with non-treated by cold plasma wound. The effect depended on the pressure sores etiology. Low-temperature plasma discharges of glow type may be considered as an effective approach to pressure sores therapy.
activation of reparative processes , antibacterial activity , biological tissues , electrolyte matrix , histology , low-temperature plasma , morphological assessments
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Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilov St., Moscow, 119991, Russian Federation
Federal State Budgetary Institution «Federal Scientific and Clinical Center of Intensive Care and Rehabilitation», 25 Petrovka St., bldg. 2, Moscow, 107031, Russian Federation
Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, 8 Trubetskaya St., bldg. 2, Moscow, 119991, Russian Federation
Institute of Cell Biophysics, FRC PSCBR, Russian Academy of Sciences, 3 Institutskaya St., Moscow region, Pushchino, 142290, Russian Federation
L.N. Gumilyov Eurasian National University, 2 Satpayev St., Nur-Sultan, 010000, Kazakhstan
Prokhorov General Physics Institute of the Russian Academy of Sciences
Federal State Budgetary Institution «Federal Scientific and Clinical Center of Intensive Care and Rehabilitation»
Sechenov First Moscow State Medical University
Institute of Cell Biophysics
L.N. Gumilyov Eurasian National University
10 лет помогаем публиковать статьи Международный издатель
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