Psoriasis: The Versatility of Mesenchymal Stem Cell and Exosome Therapies
Dairov A. Sekenova A. Alimbek S. Nurkina A. Shakhatbayev M. Kumasheva V. Kuanysh S. Adish Z. Issabekova A. Ogay V.
November 2024Multidisciplinary Digital Publishing Institute (MDPI)
Biomolecules
2024#14Issue 11
Mesenchymal stem cells (MSCs) are multilineage differentiating stromal cells with extensive immunomodulatory and anti-inflammatory properties. MSC-based therapy is widely used in the treatment of various pathologies, including bone and cartilage diseases, cardiac ischemia, diabetes, and neurological disorders. Along with MSCs, it is promising to study the therapeutic properties of exosomes derived from MSCs (MSC-Exo). A number of studies report that the therapeutic properties of MSC-Exo are superior to those of MSCs. In particular, MSC-Exo are used for tissue regeneration in various diseases, such as healing of skin wounds, cancer, coronary heart disease, lung injury, liver fibrosis, and neurological, autoimmune, and inflammatory diseases. In this regard, it is not surprising that the scientific community is interested in studying the therapeutic properties of MSCs and MSC-Exo in the treatment of psoriasis. This review summarizes the recent advancements from preclinical and clinical studies of MSCs and MSC-Exo in the treatment of psoriasis, and it also discusses their mechanisms of therapeutic action involved in the treatment of this disease.
cell therapy , clinical study , immunomodulation , in vitro , in vivo , mesenchymal stem cell , mesenchymal-stem-cell-derived exosome , preconditioning , psoriasis
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Stem Cell Laboratory, National Center for Biotechnology, Astana, 010000, Kazakhstan
Department of General Biology and Genomics, L.N. Gumilyov, Eurasian National University, Astana, 010008, Kazakhstan
Obstetrics and Gynecology, Astana Medical University, Astana, 010000, Kazakhstan
Laboratory of Immunochemistry and Immunobiotechnology, National Center for Biotechnology, Astana, 010000, Kazakhstan
Department of Natural Sciences, L.N. Gumilyov, Eurasian National University, Astana, 010008, Kazakhstan
Stem Cell Laboratory
Department of General Biology and Genomics
Obstetrics and Gynecology
Laboratory of Immunochemistry and Immunobiotechnology
Department of Natural Sciences
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