Mesenchymal Stem Cell-derived Exosomes in the Treatment of Skin and Subcutaneous Tissue Diseases: A Review
Dairov A. Issabekova A. Ogay V.
2025Bentham Science Publishers
Current Stem Cell Research and Therapy
2025
Skin and subcutaneous tissue diseases (SSTDs) are a leading cause of nonfatal disability worldwide, particularly in resource-poor regions, affecting over one-third of the worlds population. Current treatments for SSTDs include topical and oral medications, as well as mechanotherapy; however, these approaches have several significant limitations, including insufficient efficacy, side effects, and high costs. In this regard, particular interest is directed to mesenchymal stem cell-derived exosomes (MSC-Exo), the therapeutic properties of which have been actively studied worldwide in recent years. Our aim was to review clinical trials, published clinical studies, and case reports on MSC-Exo-based cell-free therapy for SSTDs, summarizing both its opportunities and challenges for clinical translation. A literature search for clinical studies and case reports of the application of MSC-Exo in the treatment of SSTDs was conducted using PubMed, Google Scholar databases, and ClinicalTrials.gov. The analysis revealed that MSC-Exo are utilized in treating diverse SSTDs, including: alopecia and hair thinning, psoriasis, facial redness in patients with atopic dermatitis, sensitive skin, melasma, skin wounds, ulcers and burns, skin aging, hyperpigmentation, scars, and dystrophic epidermolysis bullosa. Ongoing clinical trials and preliminary published clinical studies and case reports demonstrate that MSC-Exo are safe and effective cell-free therapeutic agents, highlighting their potential as a novel treatment for SSTDs.
case report , cell-free therapy , clinical study , clinical trial , extracellular vesicle , Mesenchymal stem cell , mesenchymal stem cell-derived exosome , skin and subcutaneous tissue disease
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Stem Cell Laboratory, National Center for Biotechnology, Astana, 010000, Kazakhstan
Department of General Biology and Genomics, L.N. Gumilyov, Eurasian National University, Astana, 010008, Kazakhstan
Stem Cell Laboratory
Department of General Biology and Genomics
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