Anticancer activity of new benzofuroxan–imidazolone hybrids
Chugunova E.A. Smolobochkin A.V. Gazizov A.S. Burilov A.R. Voloshina A.D. Lyubina A.P. Amerhanova S.K. Melnikova A.A. Tulesinova A.I. Akylbekov N.I. Akhatayev N.A. Syakaev V.V.
1 November 2021Elsevier Ltd
Mendeleev Communications
2021#31Issue 6865 - 866 pp.
Novel hybrid compounds containing both benzofuroxan and 1H-imidazol-2(3H)-one moieties were synthesized by an SNAr reaction between 7-chloro-4,6-dinitrobenzofuroxan and imidazol-2-ones, with the only C4 regioisomer having been formed. Cytotoxic effects of parent and obtained compounds were estimated on human cancer and normal cells, while two of imidazolones showed higher cytotoxicity in relation to the M-HeLa cancer line compared to the hybrid products. In relation to the normal liver cell line Chang, the tested compounds were found to be non-toxic and can be promising for further development of anticancer agents.
antitumor activity , benzofuroxans , hybrid compounds , imidazol-2-ones , regioselective synthesis , SNAr reaction
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A. E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of the Russian Academy of Sciences, Kazan, 420088, Russian Federation
Kazan National Research Technological University, Kazan, 420015, Russian Federation
Korkyt Ata Kyzylorda University, Kyzylorda, 120014, Kazakhstan
A. E. Arbuzov Institute of Organic and Physical Chemistry
Kazan National Research Technological University
Korkyt Ata Kyzylorda University
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