Anticancer potential of phytochemicals derived from mangrove plants: Comprehensive mechanistic insights
Chowdhury R. Bhuia M.S. Al Hasan M.S. Hossain Snigdha S. Afrin S. Büsselberg D. Habtemariam S. Sönmez Gürer E. Sharifi-Rad J. Ahmed Aldahish A. Аkhtayeva N. Islam M.T.
September 2024John Wiley and Sons Inc
Food Science and Nutrition
2024#12Issue 96174 - 6205 pp.
Cancer is a collection of illnesses characterized by aberrant cellular proliferation that can infiltrate or metastasize to distant anatomical sites, posing a notable threat to human well-being due to its substantial morbidity and death rates worldwide. The potential of plant-derived natural compounds as anticancer medicines has been assessed owing to their favorable attributes of few side effects and significant antitumor activity. Mangrove plants and their derived compounds have been scientifically shown to exhibit many significant beneficial biological activities, such as anti-inflammatory, immunomodulatory, antioxidant, neuroprotective, cardioprotective, and hepatoprotective properties. This study summarized mangrove plants and their derived compounds as potential anticancer agents, with an emphasis on the underlying molecular mechanisms. To explore this, we gathered data on the preclinical (in vivo and in vitro) anticancer effects of mangrove plants and their derived compounds from reputable literature spanning 2000 to 2023. We conducted thorough searches in various academic databases, including PubMed, ScienceDirect, Wiley Online, SpringerLink, Google Scholar, Scopus, and the Web of Science. The results demonstrated that mangrove plants and their derived compounds have promising anticancer properties in preclinical pharmacological test systems through various molecular mechanisms, including induction of oxidative stress and mitochondrial dysfunction, cytotoxicity, genotoxicity, cell cycle arrest, apoptosis, autophagy, antiproliferative, antimetastatic, and other miscellaneous actions. Upon thorough observation of the pertinent information, it is suggested that mangrove plants and their derived chemicals may serve as a potential lead in the development of novel drugs for cancer therapy.
anticancer phytochemicals , cancer , mangrove plants , molecular mechanisms
Text of the article Перейти на текст статьи
Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh
Phytochemistry and Biodiversity Research Laboratory, BioLuster Research Center, Gopalganj, Bangladesh
Pharmacy Discipline, Khulna University, Khulna, Bangladesh
Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha, Qatar
Pharmacognosy Research & Herbal Analysis Services UK, Kent, United Kingdom
Faculty of Pharmacy, Department of Pharmacognosy, Sivas Cumhuriyet University, Sivas, Turkey
Department of Biomedical Sciences, College of Medicine, Korea University, Seoul, South Korea
Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia
Department of Biodiversity and Bioresources of Al-Farabi Kazakh National University, Almaty, Kazakhstan
Department of Pharmacy
Phytochemistry and Biodiversity Research Laboratory
Pharmacy Discipline
Weill Cornell Medicine-Qatar
Pharmacognosy Research & Herbal Analysis Services UK
Faculty of Pharmacy
Department of Biomedical Sciences
Department of Pharmacology
Department of Biodiversity and Bioresources of Al-Farabi Kazakh National University
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026