Allogeneic fibroblasts vs conventional debridement after successful endovascular interventions for treating chronic ulcers induced by peripheral artery disease
Chinaliyev A. Saparbayev S. Zhakiyev B. Khassenov D. Sakhipova G. Zagorulya N. Kuanyshbayeva G. Zhampeissov N. Biktashev D. Jakanov M. Donayeva A. Abdelazim I.A.
8 July 2025Medycyna Praktyczna Cholerzyn
Wideochirurgia I Inne Techniki Maloinwazyjne
2025#20Issue 2226 - 234 pp.
INTRODUCTION Fibroblasts are stromal and connective tissue cells that play crucial roles in the intracellular matrix and granulation tissue synthesis during tissue proliferation. They are also responsible for epithelialization and healing of skin lesions. AIM Our aim was to compare the use of allogeneic fibroblasts with conventional debridement after successful endovascular interventions (EVIs) for the treatment of chronic ulcers induced by peripheral artery disease (PAD). MATERIALS AND METHODS A total of 116 participants with chronic ulcers due to PAD were randomly assigned, after successful EVI, to receive either allogeneic fibroblasts (study group; n = 58) or conventional debridement (control group; n = 58) for treatment of the ulcers. The participant data were collected over 1 year of follow‑up to compare the effectiveness of both methods. RESULTS The mean (SD) duration of initial and complete healing of chronic ulcers after successful EVI was shorter in the allogeneic fibroblast group (2.59 [0.53] and 5.04 [0.58] months, respectively) than in the controls (3.56 [0.44] and 5.8 [0.35] months, respectively; P <0.001 for all). A correlation analysis showed a moderately significant correlation between the healing of chronic ulcers (both initial and complete) after successful EVI and the use of allogeneic fibroblasts. CONCLUSIONS Allogeneic fibroblasts are an effective and noninvasive option for the treatment of chronic PAD‑induced ulcers after successful EVI. The duration of initial and complete healing was significantly shorter in the allogeneic fibroblast group than in the conventional debridement group. Copyright by the Authors, 2025.
allogeneic fibroblasts , chronic ulcers , conventional debridement , endovascular interventions , peripheral artery disease
Text of the article Перейти на текст статьи
Department of Surgical Diseases No. 2, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Interventional Radiology, National Research Oncology Center, Astana, Kazakhstan
Department of Science and Education, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of General Medicine, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Internal Diseases and Geriatrics, Astana Medical University, Astana, Kazakhstan
Department of Fundamentals of Medicine, Astana Medical University, Astana, Kazakhstan
Department of Radiation Diagnostics and Ultrasound Imaging, National Scientific Medical Centre, Astana, Kazakhstan
Department of Internal Diseases, Gastroenterology, Endocrinology and Pulmonology, Astana Medical University, Astana, Kazakhstan
Department of General Surgery, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Normal Physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Department of Surgical Diseases No. 2
Department of Interventional Radiology
Department of Science and Education
Department of General Medicine
Department of Internal Diseases and Geriatrics
Department of Fundamentals of Medicine
Department of Radiation Diagnostics and Ultrasound Imaging
Department of Internal Diseases
Department of General Surgery
Department of Normal Physiology
Department of Obstetrics and Gynecology
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026