Composite Bone Cements with Enhanced Drug Elution
Cherednichenko K. Sayfutdinova A. Rimashevskiy D. Malik B. Panchenko A. Kopitsyna M. Ragnaev S. Vinokurov V. Voronin D. Kopitsyn D.
September 2023Multidisciplinary Digital Publishing Institute (MDPI)
Polymers
2023#15Issue 18
Antibiotic-loaded bone cement (ALBC) has become an indispensable material in orthopedic surgery in recent decades, owing to the possibility of drugs delivery to the surgical site. It is applied for both infection prophylaxis (e.g., in primary joint arthroplasty) and infection treatment (e.g., in periprosthetic infection). However, the introduction of antibiotic to the polymer matrix diminishes the mechanical strength of the latter. Moreover, the majority of the loaded antibiotic remains embedded in polymer and does not participate in drug elution. Incorporation of the various additives to ALBC can help to overcome these issues. In this paper, four different natural micro/nanoscale materials (halloysite, nanocrystalline cellulose, micro- and nanofibrillated cellulose) were tested as additives to commercial Simplex P bone cement preloaded with vancomycin. The influence of all four materials on the polymerization process was comprehensively studied, including the investigation of the maximum temperature of polymerization, setting time, and monomer leaching. The introduction of the natural additives led to a considerable enhancement of drug elution and microhardness in the composite bone cements compared to ALBC. The best combination of the polymerization rate, monomer leaching, antibiotic release, and microhardness was observed for the sample containing nanofibrillated cellulose (NFC).
ALBC , antibiotic release , bone cement , nanocellulose , NFC , PMMA , vancomycin
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Department of Physical and Colloid Chemistry, Faculty of Chemical and Environmental Engineering, National University of Oil and Gas “Gubkin University”, Moscow, 119991, Russian Federation
Department of Traumatology and Orthopedics, Peoples’ Friendship University of Russia, Moscow, 117198, Russian Federation
Astana Medical University, Beybitshilik Street 49a, Astana, 010000, Kazakhstan
Russian Institute for Scientific and Technical Information “VINITI RAS”, Moscow, 125190, Russian Federation
Multidisciplinary Hospital Named after Professor Kh.Zh. Makazhanov, Karaganda, 100000, Kazakhstan
Department of Physical and Colloid Chemistry
Department of Traumatology and Orthopedics
Astana Medical University
Russian Institute for Scientific and Technical Information “VINITI RAS”
Multidisciplinary Hospital Named after Professor Kh.Zh. Makazhanov
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