Advances and Clues of Nutritional Adjuvant Therapy for Charcot-Marie-Tooth Disease

Chen Y. Zhu J. Wang M. Zhao Q. Huang C. Tarjibayeva S.K. Wang L. Sun L. Zhou J.-C.
November 2025 Elsevier B.V.

Journal of Nutrition
2025 #155 Issue 11 3642 - 3653 pp.

Charcot-Marie-Tooth disease (CMT) is an inherited peripheral neuropathy with significant genetic heterogeneity and clinical variability. Currently, there are no specific drugs to cure the disease, and adjuvant therapies are used to alleviate the symptoms. By supporting the functions of nerves, bones, and muscles, as well as systemic metabolism, personalized intakes of energy and nutrients help slow down disease progression, delay CMT onset, relieve the suffering and pain of patients, and improve their quality of life. This review discusses the research progress on energy- and fat-manipulated diets (caloric restriction diet, ketogenic diet, and high-fat diet) and several nutrients (polyunsaturated fatty acids, phospholipids, copper, iron, zinc, selenium, vitamins A/D/E/C, and some vitamin Bs) in the treatment of CMT and related peripheral neuropathies, which is expected to encourage exploration on and application of healthy diets and nutritional intakes from the viewpoint of clinical nutrition to improve the symptoms of CMT.

Charcot-Marie-Tooth disease , diet , muscle , nutrition , peripheral neuropathy

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School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, China
Health Management Center, Gansu Provincial Maternal and Child Health Hospital, Lanzhou, China
Western China School of Public Health, Sichuan University, Chengdu, China
Research Institute of Preventive Medicine named after Academician E.D.Dalenov, Astana Medical University, Astana, Kazakhstan
Faculty of Medicine, Macau University of Science and Technology, Macau, China
Guangdong Province Engineering Laboratory for Nutrition Translation, Shenzhen, China

School of Public Health (Shenzhen)
Health Management Center
Western China School of Public Health
Research Institute of Preventive Medicine named after Academician E.D.Dalenov
Faculty of Medicine
Guangdong Province Engineering Laboratory for Nutrition Translation

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