A Groundbreaking Electric Field-Induced Cascade Gas Therapy Against Large Volume Solid Tumor Through Electro-Stress Storm
Chen G. Zhang W. Wang M. Zhang F. Zhu M. Tang Y. Xie Y. Ma W. Timashev P. Bottini M. Xie Y. Liang X.-J. Yu M. Yu Z.
December 2025John Wiley and Sons Inc
Exploration
2025#5Issue 6
Gas therapy has been limited in its application as a robust standalone antitumor strategy due to the restricted gas production and cytotoxicity. To address this challenge, we employed electrotoxic PtRu composite metal nano-berries (PR) loaded with various therapeutic gas donors to construct a groundbreaking electric field-induced cascade gas therapy (EGT) platform, which generated a great electro-stress storm at tumor sites, exerting electrotoxicity and immunity functions against solid tumors, including those of large volume, through three pathways. Initially, electric field stimulation effectively boosted the release rate and yield of therapeutic gases from the EGT platform. Further, gas molecules reacted with reactive oxygen species (ROS) to either form oxidation coordination (CO and ROS) or generate more potent therapeutic components (RNS produced from ROS and NO), contributing to an electro-stress storm that augmented the cytotoxic potential of the gas components. Subsequently, this electro-stress storm further activated the tumor immune response, identifying and capturing escaped tumor cells, which held significant implications for treating tumors, including non-solid tumors with indistinct boundaries. In summary, the EGT platform leveraged an electro-stress storm to achieve ablation of large volume solid tumors and suppressed metastatic tumors, paving new pathways for gas-based therapeutic strategies.
cascade gas therapy , electric field , electro-stress storm , electrotoxicity , immunotherapy , large volume solid tumor
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Department of Laboratory Medicine, Dongguan Key Laboratory of Innovative Molecular Imaging, Dongguan Institute of Clinical Cancer Research, The Tenth Affiliated Hospital, Southern Medical University (Dongguan Peoples Hospital), Dongguan, China
Department of Hepatobiliary, Pancreatic and Splenic Surgery, The Tenth Affiliated Hospital, Southern Medical University (Dongguan Peoples Hospital), Dongguan, China
NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, China
University of Chinese Academy of Sciences, Beijing, China
Institute for Regenerative Medicine, Sechenov University, Moscow, Russian Federation
Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy
Department of Biology, School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan
Department of Laboratory Medicine
Department of Hepatobiliary
NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety
University of Chinese Academy of Sciences
Institute for Regenerative Medicine
Department of Experimental Medicine
Department of Biology
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