Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases
Chaudhary P. Janmeda P. Docea A.O. Yeskaliyeva B. Abdull Razis A.F. Modu B. Calina D. Sharifi-Rad J.
2023Frontiers Media S.A.
Frontiers in Chemistry
2023#11
Introduction: Free radicals are reactive oxygen species that constantly circulate through the body and occur as a side effect of many reactions that take place in the human body. Under normal conditions, they are removed from the body by antioxidant processes. If these natural mechanisms are disrupted, radicals accumulate in excess and contribute to the development of many diseases. Methodology: Relevant recent information on oxidative stress, free radicals, reactive oxidative species, and natural and synthetic antioxidants was collected by researching electronic databases such as PubMed / Medline, Web of Science, and Science Direct. Results: According to the analysed studies, this comprehensive review provided a recent update on oxidative stress, free radicals and antioxidants and their impact on the pathophysiology of human diseases. Discussion: To counteract the condition of oxidative stress, synthetic antioxidants must be provided from external sources to supplement the antioxidant defense mechanism internally. Because of their therapeutic potential and natural origin, medicinal plants have been reported as the main source of natural antioxidants phytocompounds. Some non-enzymatic phytocompounds such as flavonoids, polyphenols, and glutathione, along with some vitamins have been reported to possess strong antioxidant activities in vivo and in vitro studies. Thus, the present review describes, in brief, the overview of oxidative stress-directed cellular damage and the unction of dietary antioxidants in the management of different diseases. The therapeutic limitations in correlating the antioxidant activity of foods to human health were also discussed. Copyright
antioxidants , chronic diseases , free radicals , oxidative stress , pathophysiology , phytochemicals
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Department of Bioscience and Biotechnology, Banasthali University Vanasthali, Rajasthan, India
Department of Toxicology, University of Medicine and Pharmacy of Craiova, Craiova, Romania
Al-Farabi Kazakh National University, Faculty of Chemistry and Chemical Technology, Almaty, Kazakhstan
Department of Food Science, Faculty of Food` Science and Technology, Universiti Putra Malaysia, Selangor, Malaysia
Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia
Department of Biochemistry, Faculty of Science, University of Maiduguri, Maiduguri, Nigeria
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania
Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador
Department of Bioscience and Biotechnology
Department of Toxicology
Al-Farabi Kazakh National University
Department of Food Science
Natural Medicines and Products Research Laboratory
Department of Biochemistry
Department of Clinical Pharmacy
Facultad de Medicina
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